TY - JOUR
T1 - Crosstalk between long noncoding RNA and microRNA in Cancer
AU - Bhattacharjee, Rahul
AU - Prabhakar, Neeraj
AU - Kumar, Lamha
AU - Bhattacharjee, Arkadyuti
AU - Kar, Sulagna
AU - Malik, Sumira
AU - Kumar, Dhruv
AU - Ruokolainen, Janne
AU - Negi, Arvind
AU - Jha, Niraj Kumar
AU - Kesari, Kavindra Kumar
N1 - Funding Information:
We thank Aalto University for providing open-access support. NP would like to acknowledge Finnish cultural foundation (Varsinais-Suomi regional fund.)
Publisher Copyright:
© 2023, The Author(s).
PY - 2023/8
Y1 - 2023/8
N2 - miRNAs and lncRNAs play a central role in cancer-associated gene regulations. The dysregulated expression of lncRNAs has been reported as a hallmark of cancer progression, acting as an independent prediction marker for an individual cancer patient. The interplay of miRNA and lncRNA decides the variation of tumorigenesis that could be mediated by acting as sponges for endogenous RNAs, regulating miRNA decay, mediating intra-chromosomal interactions, and modulating epigenetic components. This paper focuses on the influence of crosstalk between lncRNA and miRNA on cancer hallmarks such as epithelial-mesenchymal transition, hijacking cell death, metastasis, and invasion. Other cellular roles of crosstalks, such as neovascularization, vascular mimicry, and angiogenesis were also discussed. Additionally, we reviewed crosstalk mechanism with specific host immune responses and targeting interplay (between lncRNA and miRNA) in cancer diagnosis and management. Graphic Abstract: [Figure not available: see fulltext.].
AB - miRNAs and lncRNAs play a central role in cancer-associated gene regulations. The dysregulated expression of lncRNAs has been reported as a hallmark of cancer progression, acting as an independent prediction marker for an individual cancer patient. The interplay of miRNA and lncRNA decides the variation of tumorigenesis that could be mediated by acting as sponges for endogenous RNAs, regulating miRNA decay, mediating intra-chromosomal interactions, and modulating epigenetic components. This paper focuses on the influence of crosstalk between lncRNA and miRNA on cancer hallmarks such as epithelial-mesenchymal transition, hijacking cell death, metastasis, and invasion. Other cellular roles of crosstalks, such as neovascularization, vascular mimicry, and angiogenesis were also discussed. Additionally, we reviewed crosstalk mechanism with specific host immune responses and targeting interplay (between lncRNA and miRNA) in cancer diagnosis and management. Graphic Abstract: [Figure not available: see fulltext.].
KW - Angiogenesis
KW - Cancer
KW - Epithelial-mesenchymal transition
KW - Long-noncoding RNA
KW - Metastasis
KW - MicroRNA
KW - Neovascularization
KW - Vascular mimicry
UR - http://www.scopus.com/inward/record.url?scp=85160413380&partnerID=8YFLogxK
U2 - 10.1007/s13402-023-00806-9
DO - 10.1007/s13402-023-00806-9
M3 - Review Article
C2 - 37245177
AN - SCOPUS:85160413380
SN - 2211-3428
VL - 46
SP - 885
EP - 908
JO - Cellular Oncology
JF - Cellular Oncology
IS - 4
ER -
