Could Nanotheranostics be the Answer to the Coronavirus Crisis?

Dina A. Mosselhy*, Mhd Adel Assad, Tarja Sironen, Mady Elbahri*

*Corresponding author for this work

Research output: Contribution to journalReview ArticleScientificpeer-review

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Abstract

The COVID-19 pandemic is expanding worldwide. This pandemic associated with COVID-19 placed the spotlight on how bacterial (e.g., methicillin-resistant Staphylococcus aureus) co-infections may impact responses to coronavirus. In this review the ways in which nanoparticles can contain and rapidly diagnose COVID-19 under the umbrella of nanotheranostics (i.e., smart, single agents combining nanodiagnostics and nanotherapeutics) are elaborated. The present work provides new insights into the promising incorporation of antiviral nanotheranostics into nanostructured materials, including electrospun fibers with tailored pore sizes and hydrophobicity, namely "superhydrophobic self-disinfecting electrospun facemasks/fabrics (SSEF)." SSEFs are proposed as smart alternatives to address the drawbacks of N95 respirators. The challenges of coronavirus containment are underscored, literature is reviewed, and "top-five suggestions" for containing COVID-19 are offered, including: i) preventive appraisals-avoiding needless hospital admission and practicing frequent hand washing (from 20 to 60 s). ii) Diagnostics-highly recommending nanodiagnostics, detecting COVID-19 within 10 min. iii) Therapeutics-expanding nanotherapeutics to treat COVID-19 and bacterial co-infections after safety assessments and clinical trials. iv) Multipronged and multinational, including China, collaborative appraisals. v) Humanitarian compassion to traverse this pandemic in a united way.

Original languageEnglish
Article number2000112
Number of pages13
JournalGlobal Challenges - An Innovative Journal for Tackling Humanity's Global Challenges
Volume5
Issue number6
Early online date24 Mar 2021
DOIs
Publication statusPublished - Jun 2021
MoE publication typeA2 Review article in a scientific journal

Keywords

  • anti-coronavirus
  • appraisals
  • coronavirus
  • electrospun facemasks
  • nanodiagnostics
  • nanoparticles

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