Cortical thinning of parahippocampal subregions in very early Alzheimer's disease

Sabine Krumm*, Sasa L. Kivisaari, Alphonse Probst, Andreas U. Monsch, Julia Reinhardt, Stephan Ulmer, Christoph Stippich, Reto W. Kressig, Kirsten I. Taylor

*Corresponding author for this work

Research output: Contribution to journalArticleScientificpeer-review

31 Citations (Scopus)
389 Downloads (Pure)

Abstract

The stereotypical pattern of neurofibrillary tangle spreading in the earliest stages of typical Alzheimer's dementia (AD) predicts that medial perirhinal cortex (mPRC) atrophy precedes entorhinal cortex (ERC) atrophy, whereas the status of the parahippocampal cortex (PHC) remains unclear. Atrophy studies have focused on more advanced rather than early AD patients, and usually segment the entire PRC as opposed to the mPRC versus lateral PRC (lPRC). The present study therefore determined the extent of ERC, mPRC, lPRC, and PHC atrophy in very early AD (mean Mini-Mental State Examination score = 26) patients and its presumed prodrome amnestic mild cognitive impairment (mean Mini-Mental State Examination score = 28) compared to demographically matched controls. PHG structures were manually segmented (blinded rater) and cortical thicknesses extracted. ERC and mPRC were similarly atrophied in both patient groups. The lPRC was atrophied in the AD group only. Thus, atrophic changes in very early AD broadly map onto the pattern of neurofibrillary tangle spreading and suggest that mPRC, ERC, and lPRC, but not PHC-associated functional impairments, characterize very early-stage AD.

Original languageEnglish
Pages (from-to)188-196
Number of pages9
JournalNEUROBIOLOGY OF AGING
Volume38
DOIs
Publication statusPublished - 2016
MoE publication typeA1 Journal article-refereed

Keywords

  • Perirhinal cortex
  • Entorhinal cortex
  • Parahippocampal cortex
  • Amnestic mild cognitive impairment
  • Atrophy
  • Structural MRI
  • MILD COGNITIVE IMPAIRMENT
  • HUMAN CEREBRAL-CORTEX
  • MEDIAL TEMPORAL-LOBE
  • ENTORHINAL CORTEX
  • PERIRHINAL CORTEX
  • NEUROFIBRILLARY TANGLES
  • HUMAN-BRAIN
  • MRI
  • THICKNESS
  • DECLINE

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