Core-shell designs of photoluminescent nanodiamonds with porous silica coatings for bioimaging and drug delivery II: Application

Neeraj Prabhakar, Tuomas Näreoja*, Eva von Haartman, Didem Şen Karaman, Hua Jiang, Sami Koho, Tatiana A. Dolenko, Pekka E. Hänninen, Denis I. Vlasov, Victor G. Ralchenko, Satoru Hosomi, Igor I. Vlasov, Cecilia Sahlgren, Jessica M. Rosenholm

*Corresponding author for this work

Research output: Contribution to journalArticleScientificpeer-review

78 Citations (Scopus)

Abstract

Recent advances within materials science and its interdisciplinary applications in biomedicine have emphasized the potential of using a single multifunctional composite material for concurrent drug delivery and biomedical imaging. Here we present a novel composite material consisting of a photoluminescent nanodiamond (ND) core with a porous silica (SiO2) shell. This novel multifunctional probe serves as an alternative nanomaterial to address the existing problems with delivery and subsequent tracing of the particles. Whereas the unique optical properties of ND allows for long-term live cell imaging and tracking of cellular processes, mesoporous silica nanoparticles (MSNs) have proven to be efficient drug carriers. The advantages of both ND and MSNs were hereby integrated in the new composite material, ND@MSN. The optical properties provided by the ND core rendered the nanocomposite suitable for microscopy imaging in fluorescence and reflectance mode, as well as super-resolution microscopy as a STED label; whereas the porous silica coating provided efficient intracellular delivery capacity, especially in surface-functionalized form. This study serves as a demonstration how this novel nanomaterial can be exploited for both bioimaging and drug delivery for future theranostic applications.

Original languageEnglish
Pages (from-to)3713-3722
Number of pages10
JournalNanoscale
Volume5
Issue number9
DOIs
Publication statusPublished - 7 May 2013
MoE publication typeA1 Journal article-refereed

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