“ConnectToBrain”: Synergy project for therapeutic closed-loop stimulation of brain network disorders

Ulf Ziemann*, Gian Luca Romani, Risto J. Ilmoniemi

*Corresponding author for this work

Research output: Contribution to journalReview ArticleScientificpeer-review

1 Citation (Scopus)

Abstract

Therapeutic non-invasive transcranial brain stimulation with previous treatment protocols showed at best moderate effect sizes and large interindividual variability with a substantial proportion of non-responders. A currently intensively discussed approach to address these problems is individualized closed-loop stimulation. ConnectToBrain is a synergy project funded by the European Research Council to develop noninvasive closed-loop therapeutic stimulation of network disorders of the human brain. It consists of three main pillars: (1) development of a multichannel transcranial magnetic stimulation (mTMS) coil array that covers nearly all of the cerebral cortex and enables highly precise electronic control of location, direction, intensity and timing of the induced electrical fields, (2) development of real-time analysis of activity and connectivity in brain networks using electroencephalography (EEG) for instantaneous spatial and temporal control of stimulation (brain state-dependent, closed-loop stimulation) and adaptive optimization of treatment effects by machine learning and (3) translation of these neurotechnological innovations into physiological and clinical studies.

Translated title of the contribution“ConnectToBrain”: Synergy project for therapeutic closed-loop stimulation of brain network disorders
Original languageGerman
JournalNERVENARZT
DOIs
Publication statusPublished - 1 Jan 2019
MoE publication typeA2 Review article in a scientific journal

Keywords

  • Brain network disorders
  • Electroencephalography
  • Noninvasive transcranial brain stimulation
  • Real-time analysis
  • Therapeutic brain stimulation

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