Connectivity alterations of mesostriatal pathways in first episode psychosis

Nicholas Mark Edward Alexander Hayward, Ana María Triana, Jonatan M. Panula, Tuula Kieseppä, Jaana Suvisaari, Tuukka T. Raij*

*Corresponding author for this work

Research output: Contribution to journalArticleScientificpeer-review

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Background and hypothesis: Pathogenic understanding of the psychotic disorders converges on regulation of dopaminergic signaling in mesostriatocortical pathways. Functional connectivity of the mesostriatal pathways may inform us of the neuronal networks involved. Study design: This longitudinal study of first episode psychosis (FEP) (49 patients, 43 controls) employed seed-based functional connectivity analyses of fMRI data collected during a naturalistic movie stimulus. Study results: We identified hypoconnectivity of the dorsal striatum with the midbrain, associated with antipsychotic medication dose in FEP, in comparison with the healthy control group. The midbrain regions that showed hypoconnectivity with the dorsal striatum also showed hypoconnectivity with cerebellar regions suggested to be involved in regulation of the mesostriatocortical dopaminergic pathways. None of the baseline hypoconnectivity detected was seen at follow-up. Conclusions: These findings extend earlier resting state findings on mesostriatal connectivity in psychotic disorders and highlight the potential for cerebellar regulation of the mesostriatocortical pathways as a target of treatment trials.

Original languageEnglish
Article number15
Issue number1
Publication statusPublished - Dec 2023
MoE publication typeA1 Journal article-refereed


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