Closed-loop control of reactive crystallization Part II: Polymorphism control of L-glutamic acid by sonocrystallization and seeding

Henry Hatakka*, Hannu Alatalo, Marjatta Louhi-Kultanen, Ilkka Lassila, Edward Hæggström

*Corresponding author for this work

Research output: Contribution to journalArticleScientificpeer-review

31 Citations (Scopus)

Abstract

The impact of different nucleation methods with controlled supersaturation on the polymorphism of L-glutamic acid crystals was studied in a 50dm3 semi-batch crystallizer, in which 1.5M H2SO4 was fed into a 1.5M monosodium glutamate solution. Supersaturation was controlled by a feedback loop based on measured ATR-FTIR spectra and on a thermodynamic model developed in house. Ultrasound-initiated nucleation produced pure α-polymorph (over 99.5wt%) in the end product crystals at 1mol/dm3 supersaturation. Seeded crystallization also produced almost pure a-polymorph crystals (over 93wt%), whereas spontaneous nucleation produced a polymorph mixture (from 30-70wt %) under the same operating conditions. This indicates that supersaturation-controlled sonocrystallization can be used to control polymorphism in crystals. The novelty herein is the simplicity of the method directing the generation of a desired polymorph.

Original languageEnglish
Pages (from-to)751-756
Number of pages6
JournalChemical Engineering and Technology
Volume33
Issue number5
DOIs
Publication statusPublished - May 2010
MoE publication typeA1 Journal article-refereed

Keywords

  • Crystallization
  • Polymorphism
  • Seed crystals
  • Ultrasound

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