Chemoenzymatic Hydrogen Production from Methanol Through the Interplay of Metal Complexes and Biocatalysts

Ghazal Tavakoli, Jessica E. Armstrong, Janne Naapuri, Jan Deska, Martin H. G. Prechtl

Research output: Contribution to journalArticleScientificpeer-review

5 Citations (Scopus)
132 Downloads (Pure)


Microbial methylotrophic organisms can serve as great inspiration in the development of biomimetic strategies for the dehydrogenative conversion of C1 molecules under ambient conditions. In this Concept article, a concise personal perspective on the recent advancements in the field of biomimetic catalytic models for methanol and formaldehyde conversion, in the presence and absence of enzymes and co-factors, towards the formation of hydrogen under ambient conditions is given. In particular, formaldehyde dehydrogenase mimics have been introduced in stand-alone C1-interconversion networks. Recently, coupled systems with alcohol oxidase and dehydrogenase enzymes have been also developed for in situ formation and decomposition of formaldehyde and/or reduced/oxidized nicotinamide adenine dinucleotide (NADH/ NAD+). Although C1 molecules are already used in many industries for hydrogen production, these conceptual bioinspired low-temperature energy conversion processes may lead one day to more efficient energy storage systems enabling renewable and sustainable hydrogen generation for hydrogen fuel cells under ambient conditions using C1 molecules as fuels for mobile and miniaturized energy storage solutions in which harsh conditions like those in industrial plants are not applicable.

Original languageEnglish
Pages (from-to)6474-6481
Number of pages8
Issue number26
Early online date16 Jan 2019
Publication statusPublished - 7 May 2019
MoE publication typeA1 Journal article-refereed


  • carbon dioxide
  • formaldehyde
  • dehydrogenase
  • hydrogen production
  • oxidase


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