Chemoenzymatic Dynamic Kinetic Resolution of Axially Chiral Allenes

Research output: Contribution to journalArticleScientificpeer-review

Researchers

Research units

  • Stockholm University

Abstract

Dimeric palladium bromide complexes bearing monodentate N-heterocyclic carbene ligands have been identified as efficient catalysts for the chemoselective racemization of axially chiral allenyl alcohols. In combination with porcine pancreatic lipase as biocatalyst, a dynamic kinetic resolution has been developed, giving access to optically active allenes in good yield and high enantiomeric purity.

Details

Original languageEnglish
Pages (from-to)4447-4451
Number of pages5
JournalCHEMISTRY: A EUROPEAN JOURNAL
Volume16
Issue number15
Publication statusPublished - 22 Mar 2010
MoE publication typeA1 Journal article-refereed

    Research areas

  • allenes, biocatalysis, dynamic kinetic resolution, palladium, racemization

ID: 11164025