Chemoenzymatic Dynamic Kinetic Resolution of Axially Chiral Allenes

Jan Deska, Jan-E. Bäckvall, Carolina del Pozo Ochoa

Research output: Contribution to journalArticleScientificpeer-review

Abstract

Dimeric palladium bromide complexes bearing monodentate N-heterocyclic carbene ligands have been identified as efficient catalysts for the chemoselective racemization of axially chiral allenyl alcohols. In combination with porcine pancreatic lipase as biocatalyst, a dynamic kinetic resolution has been developed, giving access to optically active allenes in good yield and high enantiomeric purity.
Original languageEnglish
Pages (from-to)4447-4451
Number of pages5
JournalCHEMISTRY: A EUROPEAN JOURNAL
Volume16
Issue number15
DOIs
Publication statusPublished - 22 Mar 2010
MoE publication typeA1 Journal article-refereed

Keywords

  • allenes
  • biocatalysis
  • dynamic kinetic resolution
  • palladium
  • racemization

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