Abstract
Ladderane lipids produced by anammox bacteria constitute some of the most structurally fascinating yet poorly studied molecules among biological membrane lipids. Slow growth of the producing organism and the inherent difficulty of purifying complex lipid mixtures have prohibited isolation of useful amounts of natural ladderane lipids. We have devised a highly selective total synthesis of ladderane lipid tails and a full phosphatidylcholine to enable biophysical studies on chemically homogeneous samples of these molecules. Additionally, we report the first proof of absolute configuration of a natural ladderane.
Original language | English |
---|---|
Pages (from-to) | 15845-15848 |
Number of pages | 4 |
Journal | Journal of the American Chemical Society |
Volume | 138 |
Issue number | 49 |
DOIs | |
Publication status | Published - 14 Dec 2016 |
MoE publication type | A1 Journal article-refereed |
Fingerprint
Dive into the research topics of 'Chemical Synthesis and Self-Assembly of a Ladderane Phospholipid'. Together they form a unique fingerprint.Datasets
-
CCDC 1527453: Experimental Crystal Structure Determination
Boxer, S. G. (Contributor), Burns, N. Z. (Contributor), Cohen, C. M. (Contributor), Mercer, J. A. M. (Contributor), Shuken, S. R. (Contributor), Smith, M. W. (Contributor), Smith, M. W. (Contributor), Vahala, R. (Creator) & Wagner, A. M. (Contributor), Cambridge Crystallographic Data Centre , 1 Jan 2017
DOI: 10.5517/ccdc.csd.cc1n8fp1, http://www.ccdc.cam.ac.uk/services/structure_request?id=doi:10.5517/ccdc.csd.cc1n8fp1&sid=DataCite
Dataset
-
CCDC 1527454: Experimental Crystal Structure Determination
Boxer, S. G. (Contributor), Burns, N. Z. (Contributor), Cohen, C. M. (Contributor), Mercer, J. A. M. (Contributor), Shuken, S. R. (Contributor), Smith, M. W. (Contributor), Smith, M. W. (Contributor), Vahala, R. (Creator) & Wagner, A. M. (Contributor), Cambridge Crystallographic Data Centre , 1 Jan 2017
DOI: 10.5517/ccdc.csd.cc1n8fq2, http://www.ccdc.cam.ac.uk/services/structure_request?id=doi:10.5517/ccdc.csd.cc1n8fq2&sid=DataCite
Dataset
-
CCDC 1527455: Experimental Crystal Structure Determination
Mercer, J. A. M. (Creator), Cohen, C. M. (Creator), Shuken, S. R. (Creator), Wagner, A. M. (Contributor), Smith, M. W. (Creator), Moss, F. R. (Creator), Smith, M. D. (Creator), Vahala, R. (Creator), Gonzalez Martinez, A. (Creator), Boxer, S. G. (Creator) & Burns, N. Z. (Creator), Cambridge Crystallographic Data Centre , 13 Jan 2017
DOI: 10.5517/ccdc.csd.cc1n8fr3, http://www.ccdc.cam.ac.uk/services/structure_request?id=doi:10.5517/ccdc.csd.cc1n8fr3&sid=DataCite
Dataset