Challenges and Perspectives of DNA Nanostructures in Biomedicine

Adrian Keller*, Veikko Linko

*Corresponding author for this work

Research output: Contribution to journalReview Articlepeer-review

111 Citations (Scopus)
86 Downloads (Pure)


DNA nanotechnology holds substantial promise for future biomedical engineering and the development of novel therapies and diagnostic assays. The subnanometer-level addressability of DNA nanostructures allows for their precise and tailored modification with numerous chemical and biological entities, which makes them fit to serve as accurate diagnostic tools and multifunctional carriers for targeted drug delivery. The absolute control over shape, size, and function enables the fabrication of tailored and dynamic devices, such as DNA nanorobots that can execute programmed tasks and react to various external stimuli. Even though several studies have demonstrated the successful operation of various biomedical DNA nanostructures both in vitro and in vivo, major obstacles remain on the path to real-world applications of DNA-based nanomedicine. Here, we summarize the current status of the field and the main implementations of biomedical DNA nanostructures. In particular, we focus on open challenges and untackled issues and discuss possible solutions.

Original languageEnglish
Pages (from-to)15818-15833
Number of pages16
JournalAngewandte Chemie - International Edition
Issue number37
Early online date29 Feb 2020
Publication statusPublished - 7 Sep 2020
MoE publication typeA2 Review article in a scientific journal


  • biocompatibility
  • diagnostics
  • DNA nanotechnology
  • drug delivery
  • nanomedicine


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