Cats and Apples: Semantic Fluency Performance for Living Things Identifies Patients with Very Early Alzheimer's Disease

Sabine Krumm; Manfred Berres; Sasa L. Kivisaari; Andreas U. Monsch; Julia Reinhardt; Maria Blatow; Reto W. Kressig; Kirsten I. Taylor

doi:10.1093/arclin/acaa109

Cats and Apples: Semantic Fluency Performance for Living Things Identifies Patients with Very Early Alzheimer's Disease

Sabine Krumm, Manfred Berres, Sasa L. Kivisaari, Andreas U. Monsch, Julia Reinhardt, Maria Blatow, Reto W. Kressig, Kirsten I. Taylor

Department of Neuroscience and Biomedical Engineering

Research output: Contribution to journal › Article › Scientific › peer-review

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Abstract

OBJECTIVE: Reduced semantic memory performance is a known neuropsychological marker of very early Alzheimer's disease (AD), but the task format that best predicts disease status is an open question. The present study aimed to identify the semantic fluency task and measure that best discriminates early-stage AD patients (PATs) from cognitively healthy controls. METHOD: Semantic fluency performance for animals, fruits, tools, and vehicles was assessed in 70 early-stage AD PATs and 67 cognitively healthy participants. Logistic regressions and receiver operating characteristics were calculated for five total score semantic fluency measures. RESULTS: Compared with all other measures, living things (i.e., total correct animals + total correct fruits) achieved highest z-statistics, highest area under the curve and smallest difference between the upper and lower 95% confidence intervals. CONCLUSION: Living things total correct is a powerful tool to detect the earliest signs of incipient AD.

Original language	English
Pages (from-to)	838-843
Number of pages	6
Journal	Archives of Clinical Neuropsychology
Volume	36
Issue number	5
DOIs	https://doi.org/10.1093/arclin/acaa109
Publication status	Published - Aug 2021
MoE publication type	A1 Journal article-refereed

Keywords

Alzheimer’s disease
Assessment
Dementia
Fluency (verbal/nonverbal)
Mild cognitive impairment

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1093/arclin/acaa109

Cats and Apples.acaa109Final published version, 398 KBLicence: CC BY-NC

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title = "Cats and Apples: Semantic Fluency Performance for Living Things Identifies Patients with Very Early Alzheimer's Disease",

abstract = "OBJECTIVE: Reduced semantic memory performance is a known neuropsychological marker of very early Alzheimer's disease (AD), but the task format that best predicts disease status is an open question. The present study aimed to identify the semantic fluency task and measure that best discriminates early-stage AD patients (PATs) from cognitively healthy controls. METHOD: Semantic fluency performance for animals, fruits, tools, and vehicles was assessed in 70 early-stage AD PATs and 67 cognitively healthy participants. Logistic regressions and receiver operating characteristics were calculated for five total score semantic fluency measures. RESULTS: Compared with all other measures, living things (i.e., total correct animals + total correct fruits) achieved highest z-statistics, highest area under the curve and smallest difference between the upper and lower 95% confidence intervals. CONCLUSION: Living things total correct is a powerful tool to detect the earliest signs of incipient AD.",

keywords = "Alzheimer{\textquoteright}s disease, Assessment, Dementia, Fluency (verbal/nonverbal), Mild cognitive impairment",

author = "Sabine Krumm and Manfred Berres and Kivisaari, {Sasa L.} and Monsch, {Andreas U.} and Julia Reinhardt and Maria Blatow and Kressig, {Reto W.} and Taylor, {Kirsten I.}",

year = "2021",

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doi = "10.1093/arclin/acaa109",

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T2 - Semantic Fluency Performance for Living Things Identifies Patients with Very Early Alzheimer's Disease

AU - Krumm, Sabine

AU - Berres, Manfred

AU - Kivisaari, Sasa L.

AU - Monsch, Andreas U.

AU - Reinhardt, Julia

AU - Blatow, Maria

AU - Kressig, Reto W.

AU - Taylor, Kirsten I.

PY - 2021/8

Y1 - 2021/8

N2 - OBJECTIVE: Reduced semantic memory performance is a known neuropsychological marker of very early Alzheimer's disease (AD), but the task format that best predicts disease status is an open question. The present study aimed to identify the semantic fluency task and measure that best discriminates early-stage AD patients (PATs) from cognitively healthy controls. METHOD: Semantic fluency performance for animals, fruits, tools, and vehicles was assessed in 70 early-stage AD PATs and 67 cognitively healthy participants. Logistic regressions and receiver operating characteristics were calculated for five total score semantic fluency measures. RESULTS: Compared with all other measures, living things (i.e., total correct animals + total correct fruits) achieved highest z-statistics, highest area under the curve and smallest difference between the upper and lower 95% confidence intervals. CONCLUSION: Living things total correct is a powerful tool to detect the earliest signs of incipient AD.

AB - OBJECTIVE: Reduced semantic memory performance is a known neuropsychological marker of very early Alzheimer's disease (AD), but the task format that best predicts disease status is an open question. The present study aimed to identify the semantic fluency task and measure that best discriminates early-stage AD patients (PATs) from cognitively healthy controls. METHOD: Semantic fluency performance for animals, fruits, tools, and vehicles was assessed in 70 early-stage AD PATs and 67 cognitively healthy participants. Logistic regressions and receiver operating characteristics were calculated for five total score semantic fluency measures. RESULTS: Compared with all other measures, living things (i.e., total correct animals + total correct fruits) achieved highest z-statistics, highest area under the curve and smallest difference between the upper and lower 95% confidence intervals. CONCLUSION: Living things total correct is a powerful tool to detect the earliest signs of incipient AD.

KW - Alzheimer’s disease

KW - Assessment

KW - Dementia

KW - Fluency (verbal/nonverbal)

KW - Mild cognitive impairment

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Cats and Apples: Semantic Fluency Performance for Living Things Identifies Patients with Very Early Alzheimer's Disease

Abstract

Keywords

UN SDGs

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