TY - JOUR
T1 - Cats and Apples
T2 - Semantic Fluency Performance for Living Things Identifies Patients with Very Early Alzheimer's Disease
AU - Krumm, Sabine
AU - Berres, Manfred
AU - Kivisaari, Sasa L.
AU - Monsch, Andreas U.
AU - Reinhardt, Julia
AU - Blatow, Maria
AU - Kressig, Reto W.
AU - Taylor, Kirsten I.
N1 - Publisher Copyright:
© The Author(s) 2020. Published by Oxford University Press. All rights reserved. For permissions, please e-mail: [email protected].
PY - 2021/8
Y1 - 2021/8
N2 - OBJECTIVE: Reduced semantic memory performance is a known neuropsychological marker of very early Alzheimer's disease (AD), but the task format that best predicts disease status is an open question. The present study aimed to identify the semantic fluency task and measure that best discriminates early-stage AD patients (PATs) from cognitively healthy controls. METHOD: Semantic fluency performance for animals, fruits, tools, and vehicles was assessed in 70 early-stage AD PATs and 67 cognitively healthy participants. Logistic regressions and receiver operating characteristics were calculated for five total score semantic fluency measures. RESULTS: Compared with all other measures, living things (i.e., total correct animals + total correct fruits) achieved highest z-statistics, highest area under the curve and smallest difference between the upper and lower 95% confidence intervals. CONCLUSION: Living things total correct is a powerful tool to detect the earliest signs of incipient AD.
AB - OBJECTIVE: Reduced semantic memory performance is a known neuropsychological marker of very early Alzheimer's disease (AD), but the task format that best predicts disease status is an open question. The present study aimed to identify the semantic fluency task and measure that best discriminates early-stage AD patients (PATs) from cognitively healthy controls. METHOD: Semantic fluency performance for animals, fruits, tools, and vehicles was assessed in 70 early-stage AD PATs and 67 cognitively healthy participants. Logistic regressions and receiver operating characteristics were calculated for five total score semantic fluency measures. RESULTS: Compared with all other measures, living things (i.e., total correct animals + total correct fruits) achieved highest z-statistics, highest area under the curve and smallest difference between the upper and lower 95% confidence intervals. CONCLUSION: Living things total correct is a powerful tool to detect the earliest signs of incipient AD.
KW - Alzheimer’s disease
KW - Assessment
KW - Dementia
KW - Fluency (verbal/nonverbal)
KW - Mild cognitive impairment
UR - http://www.scopus.com/inward/record.url?scp=85112127254&partnerID=8YFLogxK
U2 - 10.1093/arclin/acaa109
DO - 10.1093/arclin/acaa109
M3 - Article
C2 - 33237317
AN - SCOPUS:85112127254
SN - 0887-6177
VL - 36
SP - 838
EP - 843
JO - Archives of Clinical Neuropsychology
JF - Archives of Clinical Neuropsychology
IS - 5
ER -
