Cation-sensitive compartmentalization in metallacarborane containing polymer nanoparticles

Vladimir Dordovic, Mariusz Uchman, Mehedi Reza, Janne Ruokolainen, Alexander Zhigunov, Olexandr I. Ivankov, Pavel Matějíček*

*Corresponding author for this work

Research output: Contribution to journalArticleScientificpeer-review

10 Citations (Scopus)


Alkaline cations (Li+, Na+ and K+) are introduced as agents suitable to control compartmentalization in metallacarborane-rich nanoparticles of double-hydrophilic block copolymer poly(ethylene oxide)-block-poly(2-alkyloxazoline), PEO-POX. Interaction of the metallacarborane (cobalt bis(dicarbollide) anion) with PEO-POX is based mainly on dihydrogen bonding between metallacarborane boron clusters and the polymer backbone resulting in compact nanoparticles. However, the cations are a crucial factor as to whether interaction with PEO or POX segments is preferred. Changes in the bulk concentration of alkaline cations can thus provoke changes in the inner structure of polymeric nanoparticles, which is accompanied by exchange of boron clusters and alkaline cations like Li+. Because of the biomedical importance of metallacarboranes, their conjugates and also lithium salts, the hybrid nanoparticles can act as stimuli-responsive systems for drug delivery.

Original languageEnglish
Pages (from-to)9884-9892
Number of pages9
JournalRSC Advances
Issue number12
Publication statusPublished - 2016
MoE publication typeA1 Journal article-refereed

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    Dordovic, V., Uchman, M., Reza, M., Ruokolainen, J., Zhigunov, A., Ivankov, O. I., & Matějíček, P. (2016). Cation-sensitive compartmentalization in metallacarborane containing polymer nanoparticles. RSC Advances, 6(12), 9884-9892.