Cascade Catalysis Through Bifunctional Lipase Metal Biohybrids for the Synthesis of Enantioenriched O-Heterocycles from Allenes

Janne M. Naapuri, Noelia Losada-Garcia, Robin Alexander Rothemann, Manuel Carmona Pichardo, Martin H.G. Prechtl, Jose M. Palomo, Jan Deska*

*Corresponding author for this work

Research output: Contribution to journalArticleScientificpeer-review

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Abstract

Lipase/metal nanobiohybrids, generated by growth of silver or gold nanoparticles on protein matrixes are used as highly effective dual-activity heterogeneous catalysts for the production of enantiomerically enriched 2,5-dihydrofurans from allenic acetates in a one-pot cascade process combining a lipase-mediated hydrolytic kinetic resolution with a metal-catalyzed allene cycloisomerization. Incorporating a novel strategy based on enzyme-polymer bioconjugates in the nanobiohybrid preparation enables excellent conversions in the process. Candida antarctica lipase B (CALB) in combination with a dextran-based polymer modifier (DexAsp) proved to be most efficient when merged with silver nanoparticles. A range of hybrid materials were produced, combining Ag or Au metals with Thermomyces lanuginosus lipase (TLL) or CALB and its DexAsp or polyethyleneimine polymer bioconjugates. The wider applicability of the biohybrids is demonstrated by their use in allenic alcohol cyclizations, where a variety of dihydrofurans are obtained using a CALB/gold nanomaterial. These results underline the potential of the nanobiohybrid catalysis as promising approach to intricate one-pot synthetic strategies.

Original languageEnglish
Article number202200362
JournalChemCatChem
Volume14
Issue number16
Early online date22 Jun 2022
DOIs
Publication statusPublished - 19 Aug 2022
MoE publication typeA1 Journal article-refereed

Keywords

  • cascades
  • dual catalysis
  • heterocycles
  • lipases
  • nanoparticles

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