Carbonic Anhydrase Isoform VII Acts As A Molecular Switch in the Development of Synchronous Gamma-Frequency Firing of Hippocampal CA1 Pyramidal Cells

Eva Ruusuvuori, Hong Li, Kristiina Huttu, J. Matias Palva, Sergei Smirnov, Claudio Rivera, Kai Kaila, Juha Voipio*

*Corresponding author for this work

Research output: Contribution to journalArticleScientificpeer-review

112 Citations (Scopus)

Abstract

Identification of the molecular mechanisms that enable synchronous firing of CA1 pyramidal neurons is central to the understanding of the functional properties of this major hippocampal output pathway. Using microfluorescence measurements of intraneuronal pH, in situ hybridization, as well as intracellular, extracellular, and K+-sensitive microelectrode recordings, we show now that the capability for synchronous gamma-frequency (20-80 Hz) firing in response to high-frequency stimulation (HFS) emerges abruptly in the rat hippocampus at approximately postnatal day 12. This was attributable to a steep developmental upregulation of intrapyramidal carbonic anhydrase isoform VII, which acts as a key molecule in the generation of HFS-induced tonic GABAergic excitation. These results point to a crucial role for the developmental expression of intrapyramidal carbonic anhydrase VII activity in shaping integrative functions, long-term plasticity and susceptibility to epileptogenesis.

Original languageEnglish
Pages (from-to)2699-2707
Number of pages9
JournalJOURNAL OF NEUROSCIENCE
Volume24
Issue number11
DOIs
Publication statusPublished - 17 Mar 2004
MoE publication typeA1 Journal article-refereed

Keywords

  • Carbonic anhydrase
  • Epilepsy
  • Excitatory GABA
  • Gamma oscillations
  • GDP
  • Hippocampus
  • Potassium
  • Synchrony

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