TY - JOUR
T1 - Boron nitride nanotube-based amphiphilic hybrid nanomaterials for superior encapsulation of hydrophobic cargos
AU - Abu Saleh, Doaa
AU - Niskanen, Jukka
AU - Xue, Yanming
AU - Golberg, Dmitri
AU - Winnik, Françoise M.
AU - Sosnik, Alejandro
N1 - Funding Information:
DAS and AS thank the financial support of Technion (internal grant #2019300 ), the European Union's - Seventh Framework Programme under grant agreement #612765-MC-NANOTAR and the Russell Berrie Nanotechnology Institute (RBNI, Technion). DG is grateful to the Australian Research Council for granting a Laureate fellowship. Appendix A
Publisher Copyright:
© 2017 Elsevier Ltd
PY - 2017/12
Y1 - 2017/12
N2 - We report an organic-inorganic hybrid core-shell nanomaterial obtained by conjugation of an amphiphilic monomethoxy-poly(ethylene glycol)-b-poly(epsilon-caprolactone) diblock copolymer to hydroxylated boron nitride nanotubes (BNNTs). The extent of copolymer grafting reached 64% w/w, an exceptionally high value. The hybrid materials exhibit excellent physical stability in water and an outstanding loading capacity (31.3% w/w) for curcumin, a hydrophobic drug. Moreover, they present good compatibility with the Caco2 cell line, a model of intestinal epithelium. Our findings demonstrate the potential of multifunctional hybrid BNNTs to serve as a platform for complex amphiphilic nanoparticle architectures with improved features.
AB - We report an organic-inorganic hybrid core-shell nanomaterial obtained by conjugation of an amphiphilic monomethoxy-poly(ethylene glycol)-b-poly(epsilon-caprolactone) diblock copolymer to hydroxylated boron nitride nanotubes (BNNTs). The extent of copolymer grafting reached 64% w/w, an exceptionally high value. The hybrid materials exhibit excellent physical stability in water and an outstanding loading capacity (31.3% w/w) for curcumin, a hydrophobic drug. Moreover, they present good compatibility with the Caco2 cell line, a model of intestinal epithelium. Our findings demonstrate the potential of multifunctional hybrid BNNTs to serve as a platform for complex amphiphilic nanoparticle architectures with improved features.
KW - Boron nitride nanotubes
KW - Core-shell amphiphilic hybrid nanomaterials
KW - Curcumin
KW - Drug encapsulation
KW - Polymeric micelles
UR - http://www.scopus.com/inward/record.url?scp=85030323776&partnerID=8YFLogxK
U2 - 10.1016/j.mtchem.2017.09.003
DO - 10.1016/j.mtchem.2017.09.003
M3 - Article
AN - SCOPUS:85030323776
SN - 2468-5194
VL - 6
SP - 45
EP - 50
JO - Materials Today Chemistry
JF - Materials Today Chemistry
ER -