Biotemplated Lithography of Inorganic Nanostructures (BLIN) for Versatile Patterning of Functional Materials

Petteri Piskunen, Boxuan Shen, Adrian Keller, J. Jussi Toppari, Mauri A. Kostiainen*, Veikko Linko*

*Corresponding author for this work

Research output: Contribution to journalArticleScientificpeer-review

11 Citations (Scopus)


Here, we present a highly parallel fabrication method dubbed biotemplated lithography of inorganic nanostructures (BLIN) that enables large-scale versatile substrate patterning of metallic and semiconducting nanoshapes with various aspect ratios. We demonstrate the feasibility of our method by employing custom DNA origami structures and Tobacco mosaic virus (TMV) as biotemplates for pattern mask formation. Subsequently, we show high-throughput fabrication of plasmonic (Au and Ag), semiconducting (Ge), and metallic (Al and Ti) nanoparticles on substrates such as indium tin oxide coated glass and silicon wafers. The patterning ability of BLIN ranges from ∼10 to 20 nm feature sizes (with DNA origami, dimensions ∼100 nm or less) to micrometer-long nanowires (with TMV). This combination of scales and material freedom could, with further improvements, provide a cost-efficient pathway for the mass production of versatile nanopatterned surfaces with even smaller feature sizes. BLIN presents a major advantage compared to similar, previously reported techniques, as it permits the use of inexpensive and highly convenient substrates such as optical glass while simultaneously imposing minimal material restrictions on the fabricated nanostructures. Therefore, we believe our method can serve as a viable and potent alternative to current state-of-the-art approaches to produce optically active substrates with various applications in plasmonics (resonances at the visible wavelength range), biosensing (surface enhanced Raman spectroscopy), and functional metamaterials.

Original languageEnglish
Pages (from-to)529-538
Number of pages10
JournalACS Applied Nano Materials
Issue number1
Publication statusPublished - 22 Jan 2021
MoE publication typeA1 Journal article-refereed


  • DNA nanotechnology
  • DNA origami
  • lithography
  • nanofabrication
  • nanostructures
  • optics
  • virus


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