Biotechnological production of glycolic acid and ethylene glycol: current state and perspectives

Laura Salusjärvi; Sami Havukainen; Outi Koivistoinen; Mervi Toivari

doi:10.1007/s00253-019-09640-2

Biotechnological production of glycolic acid and ethylene glycol: current state and perspectives

Laura Salusjärvi^*, Sami Havukainen, Outi Koivistoinen, Mervi Toivari

^*Corresponding author for this work

Not published at Aalto University

VTT Technical Research Centre of Finland

Research output: Contribution to journal › Review Article › peer-review

105 Citations (Scopus)

Abstract

Glycolic acid (GA) and ethylene glycol (EG) are versatile two-carbon organic chemicals used in multiple daily applications. GA and EG are currently produced by chemical synthesis, but their biotechnological production from renewable resources has received a substantial interest. Several different metabolic pathways by using genetically modified microorganisms, such as Escherichia coli, Corynebacterium glutamicum and yeast have been established for their production. As a result, the yield of GA and EG produced from sugars has been significantly improved. Here, we describe the recent advancement in metabolic engineering efforts focusing on metabolic pathways and engineering strategies used for GA and EG production.

Original language	English
Pages (from-to)	2525-2535
Number of pages	11
Journal	Applied Microbiology and Biotechnology
Volume	103
Issue number	6
DOIs	https://doi.org/10.1007/s00253-019-09640-2
Publication status	Published - 15 Mar 2019
MoE publication type	A2 Review article, Literature review, Systematic review

Keywords

Biorefinery
Biotechnology
D-ribulose-1-phosphate pathway
D-xylose
D-xylulose-1-phosphate pathway
Dahms pathway
Ethylene glycol
Glycolic acid
Glyoxylate shunt
L-xylulose-1-phosphate pathway
Metabolic engineering
Serine pathway

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1007/s00253-019-09640-2

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title = "Biotechnological production of glycolic acid and ethylene glycol: current state and perspectives",

abstract = "Glycolic acid (GA) and ethylene glycol (EG) are versatile two-carbon organic chemicals used in multiple daily applications. GA and EG are currently produced by chemical synthesis, but their biotechnological production from renewable resources has received a substantial interest. Several different metabolic pathways by using genetically modified microorganisms, such as Escherichia coli, Corynebacterium glutamicum and yeast have been established for their production. As a result, the yield of GA and EG produced from sugars has been significantly improved. Here, we describe the recent advancement in metabolic engineering efforts focusing on metabolic pathways and engineering strategies used for GA and EG production.",

keywords = "Biorefinery, Biotechnology, D-ribulose-1-phosphate pathway, D-xylose, D-xylulose-1-phosphate pathway, Dahms pathway, Ethylene glycol, Glycolic acid, Glyoxylate shunt, L-xylulose-1-phosphate pathway, Metabolic engineering, Serine pathway",

author = "Laura Salusj{\"a}rvi and Sami Havukainen and Outi Koivistoinen and Mervi Toivari",

note = "Funding Information: Funding information Open access funding provided by Technical Research Centre of Finland (VTT). This study was financially supported by the Academy of Finland through the Centre of Excellence in White Biotechnology—Green Chemistry (grant 118573) and the Pentoval project (grant 129174). Publisher Copyright: {\textcopyright} 2019, The Author(s).",

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doi = "10.1007/s00253-019-09640-2",

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AU - Salusjärvi, Laura

AU - Havukainen, Sami

AU - Koivistoinen, Outi

AU - Toivari, Mervi

N1 - Funding Information: Funding information Open access funding provided by Technical Research Centre of Finland (VTT). This study was financially supported by the Academy of Finland through the Centre of Excellence in White Biotechnology—Green Chemistry (grant 118573) and the Pentoval project (grant 129174). Publisher Copyright: © 2019, The Author(s).

PY - 2019/3/15

Y1 - 2019/3/15

N2 - Glycolic acid (GA) and ethylene glycol (EG) are versatile two-carbon organic chemicals used in multiple daily applications. GA and EG are currently produced by chemical synthesis, but their biotechnological production from renewable resources has received a substantial interest. Several different metabolic pathways by using genetically modified microorganisms, such as Escherichia coli, Corynebacterium glutamicum and yeast have been established for their production. As a result, the yield of GA and EG produced from sugars has been significantly improved. Here, we describe the recent advancement in metabolic engineering efforts focusing on metabolic pathways and engineering strategies used for GA and EG production.

AB - Glycolic acid (GA) and ethylene glycol (EG) are versatile two-carbon organic chemicals used in multiple daily applications. GA and EG are currently produced by chemical synthesis, but their biotechnological production from renewable resources has received a substantial interest. Several different metabolic pathways by using genetically modified microorganisms, such as Escherichia coli, Corynebacterium glutamicum and yeast have been established for their production. As a result, the yield of GA and EG produced from sugars has been significantly improved. Here, we describe the recent advancement in metabolic engineering efforts focusing on metabolic pathways and engineering strategies used for GA and EG production.

KW - Biorefinery

KW - Biotechnology

KW - D-ribulose-1-phosphate pathway

KW - D-xylose

KW - D-xylulose-1-phosphate pathway

KW - Dahms pathway

KW - Ethylene glycol

KW - Glycolic acid

KW - Glyoxylate shunt

KW - L-xylulose-1-phosphate pathway

KW - Metabolic engineering

KW - Serine pathway

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U2 - 10.1007/s00253-019-09640-2

DO - 10.1007/s00253-019-09640-2

M3 - Review Article

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AN - SCOPUS:85061008199

SN - 0175-7598

VL - 103

SP - 2525

EP - 2535

JO - Applied Microbiology and Biotechnology

JF - Applied Microbiology and Biotechnology

IS - 6

ER -

Biotechnological production of glycolic acid and ethylene glycol: current state and perspectives

Abstract

Keywords

UN SDGs

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