Biomechanical characterization of engineered tissues and implants for tissue/organ replacement applications

Michael Gasik

Research output: Chapter in Book/Report/Conference proceedingChapterScientificpeer-review

Abstract

Biomaterials along with engineered tissues and implants are an essential part of any operations for tissue repair and regenerations. Besides chemical, mechanical, and rheology properties of templates and engineered products are very important—unfortunately, many different methods of biomechanical testing give rather different outcomes so it is not easy to obtain realistic, true properties.
Biomechanical properties are also critical to consider a proper cell culture system, and they need to be evaluated in a correct and physiologically relevant way. When cell culture systems become more specific, there are also more scientific, technical, and regulative demands to quantify the properties.
This chapter focuses on the practical biomechanical characterization of biomaterials, engineering tissues, and adjacent medical devices. It comprises the introduction of mechanobiology phenomena with a brief outline of specific properties of interest, experimental methods, and ways of data processing. It highlights possible sources of errors and misinterpretation of experimental data. Several cases are presented, and the considerations of the correct biomechanical characterization are discussed.
Original languageEnglish
Title of host publicationBiomaterials for Organ and Tissue Regeneration : New Technologies and Future Prospects
EditorsNihal Vrana, Helena Knopf-Marques, Julien Barthes
PublisherWoodhead Publishing
Chapter24
Pages599-627
Edition1
ISBN (Electronic)9780081029077
ISBN (Print)9780081029060
DOIs
Publication statusPublished - 19 Mar 2020
MoE publication typeA3 Part of a book or another research book

Publication series

NameWoodhead Publishing Series in Biomaterials

Keywords

  • biomechanics
  • biomaterials
  • mechanotransduction
  • mechanobiology
  • implants
  • interfaces

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