Biodistribution of boron after intravenous 4-dihydroxyborylphenylalanine-fructose (BPA-F) infusion in meningioma and schwannoma patients: A feasibility study for boron neutron capture therapy

Martti Kulvik; Merja Kallio; Juha Laakso; Jyrki Vähätalo; Raine Hermans; Eija Järviluoma; Anders Paetau; Merja Rasilainen; Inkeri Ruokonen; Matti Seppälä; Juha Jääskeläinen

doi:10.1016/j.apradiso.2015.08.006

Biodistribution of boron after intravenous 4-dihydroxyborylphenylalanine-fructose (BPA-F) infusion in meningioma and schwannoma patients: A feasibility study for boron neutron capture therapy

Martti Kulvik^*, Merja Kallio, Juha Laakso, Jyrki Vähätalo, Raine Hermans, Eija Järviluoma, Anders Paetau, Merja Rasilainen, Inkeri Ruokonen, Matti Seppälä, Juha Jääskeläinen

^*Corresponding author for this work

School of Business

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Abstract

We studied the uptake of boron after 100 mg/kg BPA infusion in three meningioma and five schwannoma patients as a pre-BNCT feasibility study. With average tumour-to-whole blood boron concentrations of 2.5, we discuss why BNCT could, and probably should, be developed to treat severe forms of the studied tumours. However, analysing 72 tumour and 250 blood samples yielded another finding: the plasma-to-whole blood boron concentrations varied with time, suggesting that the assumed constant boron ratio of 1:1 between normal brain tissue and whole blood deserves re-assessment.

Original language	English
Pages (from-to)	207-212
Number of pages	6
Journal	Applied Radiation and Isotopes
Volume	106
DOIs	https://doi.org/10.1016/j.apradiso.2015.08.006
Publication status	Published - 1 Dec 2015
MoE publication type	A1 Journal article-refereed

Keywords

BNCT
Meningioma
NF2
Schwannoma

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10.1016/j.apradiso.2015.08.006

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Kulvik, M., Kallio, M., Laakso, J., Vähätalo, J., Hermans, R., Järviluoma, E., Paetau, A., Rasilainen, M., Ruokonen, I., Seppälä, M., & Jääskeläinen, J. (2015). Biodistribution of boron after intravenous 4-dihydroxyborylphenylalanine-fructose (BPA-F) infusion in meningioma and schwannoma patients: A feasibility study for boron neutron capture therapy. Applied Radiation and Isotopes, 106, 207-212. https://doi.org/10.1016/j.apradiso.2015.08.006

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title = "Biodistribution of boron after intravenous 4-dihydroxyborylphenylalanine-fructose (BPA-F) infusion in meningioma and schwannoma patients: A feasibility study for boron neutron capture therapy",

abstract = "We studied the uptake of boron after 100 mg/kg BPA infusion in three meningioma and five schwannoma patients as a pre-BNCT feasibility study. With average tumour-to-whole blood boron concentrations of 2.5, we discuss why BNCT could, and probably should, be developed to treat severe forms of the studied tumours. However, analysing 72 tumour and 250 blood samples yielded another finding: the plasma-to-whole blood boron concentrations varied with time, suggesting that the assumed constant boron ratio of 1:1 between normal brain tissue and whole blood deserves re-assessment.",

keywords = "BNCT, Meningioma, NF2, Schwannoma",

author = "Martti Kulvik and Merja Kallio and Juha Laakso and Jyrki V{\"a}h{\"a}talo and Raine Hermans and Eija J{\"a}rviluoma and Anders Paetau and Merja Rasilainen and Inkeri Ruokonen and Matti Sepp{\"a}l{\"a} and Juha J{\"a}{\"a}skel{\"a}inen",

note = "No internal authors: Raine Hermans, Aalto University School of Economics, Helsinki, Finland",

year = "2015",

month = dec,

day = "1",

doi = "10.1016/j.apradiso.2015.08.006",

language = "English",

volume = "106",

pages = "207--212",

journal = "Applied Radiation and Isotopes",

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Kulvik, M, Kallio, M, Laakso, J, Vähätalo, J, Hermans, R, Järviluoma, E, Paetau, A, Rasilainen, M, Ruokonen, I, Seppälä, M & Jääskeläinen, J 2015, 'Biodistribution of boron after intravenous 4-dihydroxyborylphenylalanine-fructose (BPA-F) infusion in meningioma and schwannoma patients: A feasibility study for boron neutron capture therapy', Applied Radiation and Isotopes, vol. 106, pp. 207-212. https://doi.org/10.1016/j.apradiso.2015.08.006

Biodistribution of boron after intravenous 4-dihydroxyborylphenylalanine-fructose (BPA-F) infusion in meningioma and schwannoma patients: A feasibility study for boron neutron capture therapy. / Kulvik, Martti; Kallio, Merja; Laakso, Juha et al.
In: Applied Radiation and Isotopes, Vol. 106, 01.12.2015, p. 207-212.

Research output: Contribution to journal › Article › Scientific › peer-review

TY - JOUR

T1 - Biodistribution of boron after intravenous 4-dihydroxyborylphenylalanine-fructose (BPA-F) infusion in meningioma and schwannoma patients

T2 - A feasibility study for boron neutron capture therapy

AU - Kulvik, Martti

AU - Kallio, Merja

AU - Laakso, Juha

AU - Vähätalo, Jyrki

AU - Hermans, Raine

AU - Järviluoma, Eija

AU - Paetau, Anders

AU - Rasilainen, Merja

AU - Ruokonen, Inkeri

AU - Seppälä, Matti

AU - Jääskeläinen, Juha

N1 - No internal authors: Raine Hermans, Aalto University School of Economics, Helsinki, Finland

PY - 2015/12/1

Y1 - 2015/12/1

N2 - We studied the uptake of boron after 100 mg/kg BPA infusion in three meningioma and five schwannoma patients as a pre-BNCT feasibility study. With average tumour-to-whole blood boron concentrations of 2.5, we discuss why BNCT could, and probably should, be developed to treat severe forms of the studied tumours. However, analysing 72 tumour and 250 blood samples yielded another finding: the plasma-to-whole blood boron concentrations varied with time, suggesting that the assumed constant boron ratio of 1:1 between normal brain tissue and whole blood deserves re-assessment.

AB - We studied the uptake of boron after 100 mg/kg BPA infusion in three meningioma and five schwannoma patients as a pre-BNCT feasibility study. With average tumour-to-whole blood boron concentrations of 2.5, we discuss why BNCT could, and probably should, be developed to treat severe forms of the studied tumours. However, analysing 72 tumour and 250 blood samples yielded another finding: the plasma-to-whole blood boron concentrations varied with time, suggesting that the assumed constant boron ratio of 1:1 between normal brain tissue and whole blood deserves re-assessment.

KW - BNCT

KW - Meningioma

KW - NF2

KW - Schwannoma

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DO - 10.1016/j.apradiso.2015.08.006

M3 - Article

C2 - 26298436

AN - SCOPUS:84959471259

SN - 0969-8043

VL - 106

SP - 207

EP - 212

JO - Applied Radiation and Isotopes

JF - Applied Radiation and Isotopes

ER -

Biodistribution of boron after intravenous 4-dihydroxyborylphenylalanine-fructose (BPA-F) infusion in meningioma and schwannoma patients: A feasibility study for boron neutron capture therapy

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Keywords

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