Biodistribution of boron after intravenous 4-dihydroxyborylphenylalanine-fructose (BPA-F) infusion in meningioma and schwannoma patients: A feasibility study for boron neutron capture therapy

Martti Kulvik*, Merja Kallio, Juha Laakso, Jyrki Vähätalo, Raine Hermans, Eija Järviluoma, Anders Paetau, Merja Rasilainen, Inkeri Ruokonen, Matti Seppälä, Juha Jääskeläinen

*Corresponding author for this work

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6 Citations (Scopus)

Abstract

We studied the uptake of boron after 100 mg/kg BPA infusion in three meningioma and five schwannoma patients as a pre-BNCT feasibility study. With average tumour-to-whole blood boron concentrations of 2.5, we discuss why BNCT could, and probably should, be developed to treat severe forms of the studied tumours. However, analysing 72 tumour and 250 blood samples yielded another finding: the plasma-to-whole blood boron concentrations varied with time, suggesting that the assumed constant boron ratio of 1:1 between normal brain tissue and whole blood deserves re-assessment.

Original languageEnglish
Pages (from-to)207-212
Number of pages6
JournalAPPLIED RADIATION AND ISOTOPES
Volume106
DOIs
Publication statusPublished - 1 Dec 2015
MoE publication typeA1 Journal article-refereed

Keywords

  • BNCT
  • Meningioma
  • NF2
  • Schwannoma

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    Kulvik, M., Kallio, M., Laakso, J., Vähätalo, J., Hermans, R., Järviluoma, E., Paetau, A., Rasilainen, M., Ruokonen, I., Seppälä, M., & Jääskeläinen, J. (2015). Biodistribution of boron after intravenous 4-dihydroxyborylphenylalanine-fructose (BPA-F) infusion in meningioma and schwannoma patients: A feasibility study for boron neutron capture therapy. APPLIED RADIATION AND ISOTOPES, 106, 207-212. https://doi.org/10.1016/j.apradiso.2015.08.006