Bariatric Surgery Induces White and Grey Matter Density Recovery in the Morbidly Obese: A Voxel-Based Morphometric Study

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Bariatric Surgery Induces White and Grey Matter Density Recovery in the Morbidly Obese : A Voxel-Based Morphometric Study. / Tuulari, Jetro J.; Karlsson, Henry K.; Antikainen, Olli; Hirvonen, Jussi; Pham, Tam; Salminen, Paulina; Helmiö, Mika; Parkkola, Riitta; Nuutila, Pirjo; Nummenmaa, Lauri.

In: Human Brain Mapping , Vol. 37, No. 11, 10.2016, p. 3745–3756.

Research output: Contribution to journalArticleScientificpeer-review

Harvard

Tuulari, JJ, Karlsson, HK, Antikainen, O, Hirvonen, J, Pham, T, Salminen, P, Helmiö, M, Parkkola, R, Nuutila, P & Nummenmaa, L 2016, 'Bariatric Surgery Induces White and Grey Matter Density Recovery in the Morbidly Obese: A Voxel-Based Morphometric Study' Human Brain Mapping , vol. 37, no. 11, pp. 3745–3756. https://doi.org/10.1002/hbm.23272

APA

Tuulari, J. J., Karlsson, H. K., Antikainen, O., Hirvonen, J., Pham, T., Salminen, P., ... Nummenmaa, L. (2016). Bariatric Surgery Induces White and Grey Matter Density Recovery in the Morbidly Obese: A Voxel-Based Morphometric Study. Human Brain Mapping , 37(11), 3745–3756. https://doi.org/10.1002/hbm.23272

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Tuulari, Jetro J. ; Karlsson, Henry K. ; Antikainen, Olli ; Hirvonen, Jussi ; Pham, Tam ; Salminen, Paulina ; Helmiö, Mika ; Parkkola, Riitta ; Nuutila, Pirjo ; Nummenmaa, Lauri. / Bariatric Surgery Induces White and Grey Matter Density Recovery in the Morbidly Obese : A Voxel-Based Morphometric Study. In: Human Brain Mapping . 2016 ; Vol. 37, No. 11. pp. 3745–3756.

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@article{4013cde7571c43a1878930196b0d52ae,
title = "Bariatric Surgery Induces White and Grey Matter Density Recovery in the Morbidly Obese: A Voxel-Based Morphometric Study",
abstract = "Obesity is associated with lowered brain's grey (GM) and white matter (WM) density as measured by voxel-based morphometry (VBM). Nevertheless, it remains unknown whether obesity has a causal influence on cerebral atrophy. We recruited 47 morbidly obese subjects (mean BMI=42.2, SD=4.0, 42 females and five males) eligible for bariatric surgery and 29 non-obese subjects (mean BMI=23.2, SD=2.8, 23 females and six males) served as controls. Baseline scans were acquired with T1-weighted magnetic resonance imaging (MRI) at 1.5 Tesla; obese participants were scanned again six months after the surgery. Local GM and WM densities were quantified using VBM. Full-volume analyses were used for comparing baseline between-group differences as well as the effects of surgery-induced weight loss in the morbidly obese. Metabolic variables were used in linear models to predict WM and GM densities. Obese subjects had initially lower GM densities in widespread cortical areas including frontal, parietal, and temporal regions as well as insulae. Lower WM densities were observed throughout the WM. Bariatric surgery and concomitant weight loss resulted in global increase in WM density. Grey matter increase was limited to occipital and inferior temporal regions. Metabolic variables were associated with brain densities. We conclude that weight loss results in global recovery of WM as well as local recovery of grey matter densities. These changes likely reflect improved brain tissue integrity.",
keywords = "Bariatric surgery, Obesity, Structural MRI, Voxel-based morphometry, Weight loss",
author = "Tuulari, {Jetro J.} and Karlsson, {Henry K.} and Olli Antikainen and Jussi Hirvonen and Tam Pham and Paulina Salminen and Mika Helmi{\"o} and Riitta Parkkola and Pirjo Nuutila and Lauri Nummenmaa",
year = "2016",
month = "10",
doi = "10.1002/hbm.23272",
language = "English",
volume = "37",
pages = "3745–3756",
journal = "Human Brain Mapping",
issn = "1065-9471",
publisher = "John Wiley & Sons Inc.",
number = "11",

}

RIS - Download

TY - JOUR

T1 - Bariatric Surgery Induces White and Grey Matter Density Recovery in the Morbidly Obese

T2 - A Voxel-Based Morphometric Study

AU - Tuulari, Jetro J.

AU - Karlsson, Henry K.

AU - Antikainen, Olli

AU - Hirvonen, Jussi

AU - Pham, Tam

AU - Salminen, Paulina

AU - Helmiö, Mika

AU - Parkkola, Riitta

AU - Nuutila, Pirjo

AU - Nummenmaa, Lauri

PY - 2016/10

Y1 - 2016/10

N2 - Obesity is associated with lowered brain's grey (GM) and white matter (WM) density as measured by voxel-based morphometry (VBM). Nevertheless, it remains unknown whether obesity has a causal influence on cerebral atrophy. We recruited 47 morbidly obese subjects (mean BMI=42.2, SD=4.0, 42 females and five males) eligible for bariatric surgery and 29 non-obese subjects (mean BMI=23.2, SD=2.8, 23 females and six males) served as controls. Baseline scans were acquired with T1-weighted magnetic resonance imaging (MRI) at 1.5 Tesla; obese participants were scanned again six months after the surgery. Local GM and WM densities were quantified using VBM. Full-volume analyses were used for comparing baseline between-group differences as well as the effects of surgery-induced weight loss in the morbidly obese. Metabolic variables were used in linear models to predict WM and GM densities. Obese subjects had initially lower GM densities in widespread cortical areas including frontal, parietal, and temporal regions as well as insulae. Lower WM densities were observed throughout the WM. Bariatric surgery and concomitant weight loss resulted in global increase in WM density. Grey matter increase was limited to occipital and inferior temporal regions. Metabolic variables were associated with brain densities. We conclude that weight loss results in global recovery of WM as well as local recovery of grey matter densities. These changes likely reflect improved brain tissue integrity.

AB - Obesity is associated with lowered brain's grey (GM) and white matter (WM) density as measured by voxel-based morphometry (VBM). Nevertheless, it remains unknown whether obesity has a causal influence on cerebral atrophy. We recruited 47 morbidly obese subjects (mean BMI=42.2, SD=4.0, 42 females and five males) eligible for bariatric surgery and 29 non-obese subjects (mean BMI=23.2, SD=2.8, 23 females and six males) served as controls. Baseline scans were acquired with T1-weighted magnetic resonance imaging (MRI) at 1.5 Tesla; obese participants were scanned again six months after the surgery. Local GM and WM densities were quantified using VBM. Full-volume analyses were used for comparing baseline between-group differences as well as the effects of surgery-induced weight loss in the morbidly obese. Metabolic variables were used in linear models to predict WM and GM densities. Obese subjects had initially lower GM densities in widespread cortical areas including frontal, parietal, and temporal regions as well as insulae. Lower WM densities were observed throughout the WM. Bariatric surgery and concomitant weight loss resulted in global increase in WM density. Grey matter increase was limited to occipital and inferior temporal regions. Metabolic variables were associated with brain densities. We conclude that weight loss results in global recovery of WM as well as local recovery of grey matter densities. These changes likely reflect improved brain tissue integrity.

KW - Bariatric surgery

KW - Obesity

KW - Structural MRI

KW - Voxel-based morphometry

KW - Weight loss

UR - http://www.scopus.com/inward/record.url?scp=84979220616&partnerID=8YFLogxK

U2 - 10.1002/hbm.23272

DO - 10.1002/hbm.23272

M3 - Article

VL - 37

SP - 3745

EP - 3756

JO - Human Brain Mapping

JF - Human Brain Mapping

SN - 1065-9471

IS - 11

ER -

ID: 6964286