Bacterial Cellulose: Functional Modification and Wound Healing Applications

Wei He, Jian Wu, Jin Xu, Dina A. Mosselhy, Yudong Zheng*, Siming Yang*

*Corresponding author for this work

Research output: Contribution to journalReview Articlepeer-review

27 Citations (Scopus)


Significance: Wound dressings are frequently used for wound covering and healing. Ideal wound dressings should provide a moist environment for wounds and actively promote wound healing and skin recovery. The materials used as ideal wound dressings should possess specific properties, thus accelerating skin tissue regeneration process. 

Recent Advances: Bacterial cellulose (BC) is a natural polymer synthesized by some bacteria. As a kind of natural biopolymer, BC shows good biological activity, biodegradability, and biological adaptability. It has many unique physical, chemical, and biological properties, such as ultrafine nanofiber network, high crystallinity, high water absorption and retention capacity, and high tensile strength and elastic modulus. These excellent properties of BC have laid the foundation for its application as dressing in wound healing. 

Critical Issues: To optimize the biocompatibility and antimicrobial activity of BC, different methods including microbial fermentation, physical modification, chemical modification, and compound modification have been adopted to modify BC to ensure a better application in wound healing. BC-based wound dressings have been applied in infected wounds, acute traumatic injuries, burns, and diabetic wounds, showing remarkable therapeutic effects on promoting wound healing. Furthermore, there have been some commercial BC-based dressings and they have been utilized in clinical practice. 

Future Directions: Because of its excellent physicochemical characteristics and biological properties, BC shows high clinical value to be used as a wound dressing for skin tissue regeneration.

Original languageEnglish
Pages (from-to)623-640
Number of pages18
Issue number11
Early online date13 Aug 2021
Publication statusPublished - 1 Nov 2021
MoE publication typeA2 Review article in a scientific journal


  • bacterial cellulose
  • functional modification
  • wound dressing
  • wound healing


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