Bacterial adherence to silver nitrate coated poly-L-lactic acid urological stents in vitro

Markku Multanen*, Martti Talja, Saija Hallanvuo, Anja Siitonen, Tero Välimaa, Teuvo L. J. Tammela, Jukka Seppälä, Pertti Törmälä

*Corresponding author for this work

    Research output: Contribution to journalArticleScientificpeer-review

    14 Citations (Scopus)

    Abstract

    The purpose of this study was to see whether it is possible to prevent bacterial adherence to bioabsorbable self-reinforced L-lactic acid polymer (SR-PLLA) urological stents. The SR-PLLA stems were coated with silver nitrate blended ε-caprolactone/L-lactide copolymer. The adherence of five bacterial strains (Pseudomonas aeruginosa, Enterococcus faecalis, Proteus mirabilis and two strains of Escherichia coli) to coated and non-coated SR-PLLA wires were tested. It was found that silver nitrate coating prevented the adherence of bacteria (except E. faecalis) to SR-PLLA stems. The preventive effect correlated with the silver nitrate concentration. It was also found that silver nitrate coating reduced the amount of bacteria in ambient urine. In conclusion, silver nitrate coating may reduce stent-associated bacterial infections by preventing the adherence of bacteria. Further studies are needed to confirm its efficacy and safety in clinical practice.

    Original languageEnglish
    Pages (from-to)327-331
    Number of pages5
    JournalUROLOGICAL RESEARCH
    Volume28
    Issue number5
    DOIs
    Publication statusPublished - 2000
    MoE publication typeA1 Journal article-refereed

    Keywords

    • Biodegradation
    • Infection
    • Stents
    • Urology

    Fingerprint Dive into the research topics of 'Bacterial adherence to silver nitrate coated poly-L-lactic acid urological stents in vitro'. Together they form a unique fingerprint.

    Cite this