Attenuated beta rebound to proprioceptive afferent feedback in Parkinson’s disease

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Attenuated beta rebound to proprioceptive afferent feedback in Parkinson’s disease. / Vinding, Mikkel C.; Tsitsi, Panagiota; Piitulainen, Harri; Waldthaler, Josefine; Jousmäki, Veikko; Ingvar, Martin; Svenningsson, Per; Lundqvist, Daniel.

In: Scientific Reports, Vol. 9, No. 1, 2604, 22.02.2019, p. 1-11.

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Vinding, MC, Tsitsi, P, Piitulainen, H, Waldthaler, J, Jousmäki, V, Ingvar, M, Svenningsson, P & Lundqvist, D 2019, 'Attenuated beta rebound to proprioceptive afferent feedback in Parkinson’s disease' Scientific Reports, vol. 9, no. 1, 2604, pp. 1-11. https://doi.org/10.1038/s41598-019-39204-3

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Vinding, Mikkel C. ; Tsitsi, Panagiota ; Piitulainen, Harri ; Waldthaler, Josefine ; Jousmäki, Veikko ; Ingvar, Martin ; Svenningsson, Per ; Lundqvist, Daniel. / Attenuated beta rebound to proprioceptive afferent feedback in Parkinson’s disease. In: Scientific Reports. 2019 ; Vol. 9, No. 1. pp. 1-11.

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@article{c951c3d1184343acbd84cb507ede4d2d,
title = "Attenuated beta rebound to proprioceptive afferent feedback in Parkinson’s disease",
abstract = "Motor symptoms are defining traits in the diagnosis of Parkinson’s disease (PD). A crucial component in motor function is the integration of afferent proprioceptive sensory feedback. Previous studies have indicated abnormal movement-related cortical oscillatory activity in PD, but the role of the proprioceptive afference on abnormal oscillatory activity in PD has not been elucidated. We examine the cortical oscillations in the mu/beta-band (8–30 Hz) in the processing of proprioceptive stimulation in PD patients, ON/OFF levodopa medication, as compared to that of healthy controls (HC). We used a proprioceptive stimulator that generated precisely controlled passive movements of the index finger and measured the induced cortical oscillatory responses following the proprioceptive stimulation using magnetoencephalography. Both PD patients and HC showed a typical beta-band desynchronization during the passive movement. However, the subsequent beta rebound after the passive movement that was almost absent in PD patients compared to HC. Furthermore, we found no difference in the degree of beta rebound attenuation between patients ON and OFF levodopa medication. The results demonstrate a disease-related deterioration in cortical processing of proprioceptive afference in PD.",
author = "Vinding, {Mikkel C.} and Panagiota Tsitsi and Harri Piitulainen and Josefine Waldthaler and Veikko Jousm{\"a}ki and Martin Ingvar and Per Svenningsson and Daniel Lundqvist",
year = "2019",
month = "2",
day = "22",
doi = "10.1038/s41598-019-39204-3",
language = "English",
volume = "9",
pages = "1--11",
journal = "Scientific Reports",
issn = "2045-2322",
number = "1",

}

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TY - JOUR

T1 - Attenuated beta rebound to proprioceptive afferent feedback in Parkinson’s disease

AU - Vinding, Mikkel C.

AU - Tsitsi, Panagiota

AU - Piitulainen, Harri

AU - Waldthaler, Josefine

AU - Jousmäki, Veikko

AU - Ingvar, Martin

AU - Svenningsson, Per

AU - Lundqvist, Daniel

PY - 2019/2/22

Y1 - 2019/2/22

N2 - Motor symptoms are defining traits in the diagnosis of Parkinson’s disease (PD). A crucial component in motor function is the integration of afferent proprioceptive sensory feedback. Previous studies have indicated abnormal movement-related cortical oscillatory activity in PD, but the role of the proprioceptive afference on abnormal oscillatory activity in PD has not been elucidated. We examine the cortical oscillations in the mu/beta-band (8–30 Hz) in the processing of proprioceptive stimulation in PD patients, ON/OFF levodopa medication, as compared to that of healthy controls (HC). We used a proprioceptive stimulator that generated precisely controlled passive movements of the index finger and measured the induced cortical oscillatory responses following the proprioceptive stimulation using magnetoencephalography. Both PD patients and HC showed a typical beta-band desynchronization during the passive movement. However, the subsequent beta rebound after the passive movement that was almost absent in PD patients compared to HC. Furthermore, we found no difference in the degree of beta rebound attenuation between patients ON and OFF levodopa medication. The results demonstrate a disease-related deterioration in cortical processing of proprioceptive afference in PD.

AB - Motor symptoms are defining traits in the diagnosis of Parkinson’s disease (PD). A crucial component in motor function is the integration of afferent proprioceptive sensory feedback. Previous studies have indicated abnormal movement-related cortical oscillatory activity in PD, but the role of the proprioceptive afference on abnormal oscillatory activity in PD has not been elucidated. We examine the cortical oscillations in the mu/beta-band (8–30 Hz) in the processing of proprioceptive stimulation in PD patients, ON/OFF levodopa medication, as compared to that of healthy controls (HC). We used a proprioceptive stimulator that generated precisely controlled passive movements of the index finger and measured the induced cortical oscillatory responses following the proprioceptive stimulation using magnetoencephalography. Both PD patients and HC showed a typical beta-band desynchronization during the passive movement. However, the subsequent beta rebound after the passive movement that was almost absent in PD patients compared to HC. Furthermore, we found no difference in the degree of beta rebound attenuation between patients ON and OFF levodopa medication. The results demonstrate a disease-related deterioration in cortical processing of proprioceptive afference in PD.

UR - http://www.scopus.com/inward/record.url?scp=85062003665&partnerID=8YFLogxK

U2 - 10.1038/s41598-019-39204-3

DO - 10.1038/s41598-019-39204-3

M3 - Article

VL - 9

SP - 1

EP - 11

JO - Scientific Reports

JF - Scientific Reports

SN - 2045-2322

IS - 1

M1 - 2604

ER -

ID: 32385264