Asymmetric synthesis of Pachastrissamine (Jaspine B) and its diastereomers via ?3-allylpalladium intermediates

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Abstract

A short route for the synthesis of Pachastrissamine (Jaspine B), an anhydrosphingosine derivative, and all three of its diastereomers is presented. The route consists of only 9 steps from the commercially available Garner’s aldehyde. The furan framework is formed via an h3-allylpalladium intermediate.

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Original languageEnglish
Pages (from-to)1774-1783
JournalORGANIC AND BIOMOLECULAR CHEMISTRY
Volume9
Issue number6
Publication statusPublished - 2011
MoE publication typeA1 Journal article-refereed

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