Asymmetric Synthesis of 2,3,4-Trisubstituted Piperidines

Kadri Kriis; Triin Melnik; Kristiina Lips; Ilona Juhanson; Sandra Kaabel; Ivar Järving; Tõnis Kanger

doi:10.1055/s-0036-1588299

Asymmetric Synthesis of 2,3,4-Trisubstituted Piperidines

Kadri Kriis, Triin Melnik, Kristiina Lips, Ilona Juhanson, Sandra Kaabel, Ivar Järving, Tõnis Kanger^*

^*Corresponding author for this work

Not published at Aalto University

Tallinn University of Technology

Research output: Contribution to journal › Article › Scientific › peer-review

8 Citations (Scopus)

Abstract

Two different organocatalytic approaches for the asymmetric synthesis of 2,3,4-trisubstituted piperidines were developed. Both approaches were based on an aza-Michael addition followed by cyclization and gave products in high enantiomeric excess.

Original language	English
Article number	ss-2016-t0463-op
Pages (from-to)	604-614
Number of pages	11
Journal	Synthesis (Germany)
Volume	49
Issue number	3
DOIs	https://doi.org/10.1055/s-0036-1588299
Publication status	Published - 1 Feb 2017
MoE publication type	A1 Journal article-refereed

Keywords

asymmetric catalysis
aza-Michael addition
cyclization
organocatalysis
trisubstituted piperidines

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10.1055/s-0036-1588299

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title = "Asymmetric Synthesis of 2,3,4-Trisubstituted Piperidines",

abstract = "Two different organocatalytic approaches for the asymmetric synthesis of 2,3,4-trisubstituted piperidines were developed. Both approaches were based on an aza-Michael addition followed by cyclization and gave products in high enantiomeric excess.",

keywords = "asymmetric catalysis, aza-Michael addition, cyclization, organocatalysis, trisubstituted piperidines",

author = "Kadri Kriis and Triin Melnik and Kristiina Lips and Ilona Juhanson and Sandra Kaabel and Ivar J{\"a}rving and T{\~o}nis Kanger",

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AU - Kriis, Kadri

AU - Melnik, Triin

AU - Lips, Kristiina

AU - Juhanson, Ilona

AU - Kaabel, Sandra

AU - Järving, Ivar

AU - Kanger, Tõnis

PY - 2017/2/1

Y1 - 2017/2/1

N2 - Two different organocatalytic approaches for the asymmetric synthesis of 2,3,4-trisubstituted piperidines were developed. Both approaches were based on an aza-Michael addition followed by cyclization and gave products in high enantiomeric excess.

AB - Two different organocatalytic approaches for the asymmetric synthesis of 2,3,4-trisubstituted piperidines were developed. Both approaches were based on an aza-Michael addition followed by cyclization and gave products in high enantiomeric excess.

KW - asymmetric catalysis

KW - aza-Michael addition

KW - cyclization

KW - organocatalysis

KW - trisubstituted piperidines

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ER -

Asymmetric Synthesis of 2,3,4-Trisubstituted Piperidines

Abstract

Keywords

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