Asymmetric Synthesis of 2,3,4-Trisubstituted Piperidines

Kadri Kriis, Triin Melnik, Kristiina Lips, Ilona Juhanson, Sandra Kaabel, Ivar Järving, Tõnis Kanger*

*Corresponding author for this work

Research output: Contribution to journalArticleScientificpeer-review

5 Citations (Scopus)


Two different organocatalytic approaches for the asymmetric synthesis of 2,3,4-trisubstituted piperidines were developed. Both approaches were based on an aza-Michael addition followed by cyclization and gave products in high enantiomeric excess.

Original languageEnglish
Article numberss-2016-t0463-op
Pages (from-to)604-614
Number of pages11
JournalSynthesis (Germany)
Issue number3
Publication statusPublished - 1 Feb 2017
MoE publication typeA1 Journal article-refereed


  • asymmetric catalysis
  • aza-Michael addition
  • cyclization
  • organocatalysis
  • trisubstituted piperidines


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