Asymmetric organocatalytic Michael addition of Meldrum's acid to nitroalkenes: probing the mechanism of bifunctional thiourea organocatalysts

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Original languageEnglish
Pages (from-to)205-223
JournalArkivoc
Publication statusPublished - 2010
MoE publication typeA1 Journal article-refereed

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Abstract

The asymmetric Michael addition of Meldrum’s acid to nitroalkenes was studied using a novel type of Cinchona alkaloid-based bifunctional thiourea organocatalyst. The functionality of the thiourea catalysts was also probed by preparing and testing thiourea-N-methylated analogues of the well-known bis-(3,5-trifluoromethyl)phenyl-substituted catalyst.

    Research areas

  • Asymmetric, organocatalytics, Michael addition, bifunctional thiourea catalysts, cinchona alkaloids, Meldrum's acid

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