The asymmetric Michael addition of Meldrum’s acid to nitroalkenes was studied using a novel type of Cinchona alkaloid-based bifunctional thiourea organocatalyst. The functionality of the thiourea catalysts was also probed by preparing and testing thiourea-N-methylated analogues of the well-known bis-(3,5-trifluoromethyl)phenyl-substituted catalyst.
|Publication status||Published - 2010|
|MoE publication type||A1 Journal article-refereed|
- Michael addition
- bifunctional thiourea catalysts
- cinchona alkaloids
- Meldrum's acid