Asymmetric organocatalytic Michael addition of Meldrum's acid to nitroalkenes: probing the mechanism of bifunctional thiourea organocatalysts

Antti O. Kataja, Ari M.P. Koskinen

    Research output: Contribution to journalArticleScientificpeer-review

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    Abstract

    The asymmetric Michael addition of Meldrum’s acid to nitroalkenes was studied using a novel type of Cinchona alkaloid-based bifunctional thiourea organocatalyst. The functionality of the thiourea catalysts was also probed by preparing and testing thiourea-N-methylated analogues of the well-known bis-(3,5-trifluoromethyl)phenyl-substituted catalyst.
    Original languageEnglish
    Pages (from-to)205-223
    JournalArkivoc
    Publication statusPublished - 2010
    MoE publication typeA1 Journal article-refereed

    Keywords

    • Asymmetric
    • organocatalytics
    • Michael addition
    • bifunctional thiourea catalysts
    • cinchona alkaloids
    • Meldrum's acid

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