Abstract
The asymmetric Michael addition of Meldrum’s acid to nitroalkenes was studied using a novel type of Cinchona alkaloid-based bifunctional thiourea organocatalyst. The functionality of the thiourea catalysts was also probed by preparing and testing thiourea-N-methylated analogues of the well-known bis-(3,5-trifluoromethyl)phenyl-substituted catalyst.
| Original language | English |
|---|---|
| Pages (from-to) | 205-223 |
| Journal | Arkivoc |
| Publication status | Published - 2010 |
| MoE publication type | A1 Journal article-refereed |
Keywords
- Asymmetric
- organocatalytics
- Michael addition
- bifunctional thiourea catalysts
- cinchona alkaloids
- Meldrum's acid