Asymmetric organocatalytic Michael addition of Meldrum's acid to nitroalkenes: probing the mechanism of bifunctional thiourea organocatalysts

Antti O. Kataja; Ari M.P. Koskinen

Asymmetric organocatalytic Michael addition of Meldrum's acid to nitroalkenes: probing the mechanism of bifunctional thiourea organocatalysts

Antti O. Kataja, Ari M.P. Koskinen

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Abstract

The asymmetric Michael addition of Meldrum’s acid to nitroalkenes was studied using a novel type of Cinchona alkaloid-based bifunctional thiourea organocatalyst. The functionality of the thiourea catalysts was also probed by preparing and testing thiourea-N-methylated analogues of the well-known bis-(3,5-trifluoromethyl)phenyl-substituted catalyst.

Original language	English
Pages (from-to)	205-223
Journal	Arkivoc
Publication status	Published - 2010
MoE publication type	A1 Journal article-refereed

Keywords

Asymmetric
organocatalytics
Michael addition
bifunctional thiourea catalysts
cinchona alkaloids
Meldrum's acid

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Kataja, A. O., & Koskinen, A. M. P. (2010). Asymmetric organocatalytic Michael addition of Meldrum's acid to nitroalkenes: probing the mechanism of bifunctional thiourea organocatalysts. Arkivoc, 205-223.

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KW - Asymmetric

KW - organocatalytics

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KW - cinchona alkaloids

KW - Meldrum's acid

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