Assembly of Gold Nanorods into Chiral Plasmonic Metamolecules Using DNA Origami Templates

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Abstract

The inherent addressability of DNA origami structures makes them ideal templates for the arrangement of metal nanoparticles into complex plasmonic nanostructures. The high spatial precision of a DNA origami-templated assembly allows controlling the coupling between plasmonic resonances of individual particles and enables tailoring optical properties of the constructed nanostructures. Recently, chiral plasmonic systems attracted a lot of attention due to the strong correlation between the spatial configuration of plasmonic assemblies and their optical responses (e.g., circular dichroism [CD]). In this protocol, we describe the whole workflow for the generation of DNA origami-based chiral assemblies of gold nanorods (AuNRs). The protocol includes a detailed description of the design principles and experimental procedures for the fabrication of DNA origami templates, the synthesis of AuNRs, and the assembly of origami-AuNR structures. In addition, the characterization of structures using transmission electron microscopy (TEM) and CD spectroscopy is included. The described protocol is not limited to chiral configurations and can be adapted for the construction of various plasmonic architectures.
Original languageEnglish
Article numbere59280
Pages (from-to)1-8
Number of pages8
JournalJournal of Visualized Experiments
Volume145
Issue number145
DOIs
Publication statusPublished - 5 Mar 2019
MoE publication typeA1 Journal article-refereed

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  • Projects

    DNA-based devices for detection and sensing of biomolecular interactions

    Ryssy, J., Natarajan, A. & Kuzyk, A.

    01/09/201731/08/2021

    Project: Academy of Finland: Other research funding

    Equipment

    OtaNano

    Anna Rissanen (Manager)

    Aalto University

    Facility/equipment: Facility

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