Projects per year
Abstract
The one-pot combination of halogenation biocatalysis and Suzuki-type cross coupling enables the direct arylative cyclization of allenic alcohols with boronic acids. This modular approach to unsaturated five-membered O-heterocycles proceeds in an aqueous emulsion with air as terminal oxidant. Here, the enzymatic oxidative activation of simple halide salts acts as traceless ring-closure-inducing event to trigger the subsequent C−C coupling. With the original protocol merging soluble proteins and a homogeneous SPhos-based palladium catalyst as a template, a novel heterogeneous nanobiohybrid was developed. Consisting of an oxidase matrix hosting small spherical palladium nanoparticles, this enzyme-metal hybrid exhibits catalytic competence for both the biocyclization as well as the C−C bond-forming cross coupling, underlining the potential of this new techniques for streamlining chemoenzymatic approaches.
Original language | English |
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Pages (from-to) | 763-769 |
Number of pages | 7 |
Journal | ChemCatChem |
Volume | 13 |
Issue number | 2 |
Early online date | 4 Nov 2020 |
DOIs | |
Publication status | Published - 20 Jan 2021 |
MoE publication type | A1 Journal article-refereed |
Keywords
- cascades
- chemoenzymatic
- cross coupling
- heterocycles
- nanoparticles
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Dive into the research topics of 'Arylative Allenol Cyclization via Sequential One-pot Enzyme & Palladium Catalysis'. Together they form a unique fingerprint.Projects
- 2 Finished
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MOCCA: Molybdenum Catalysts for C1-Carbon Valorisation
Deska, J.
01/01/2019 → 31/01/2020
Project: Academy of Finland: Other research funding
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Beyond Biosynthesis: Enzymes as Catalysts in Non-natural Synthetic Transformations
Deska, J., Naapuri, J., Liu, Y., Blume, F., Jäger, C. & Kiefer, A.
01/09/2016 → 31/03/2021
Project: Academy of Finland: Other research funding