Anti-neuronal anti-bodies in patients with early psychosis

Outi Mantere, Miiamaaria Saarela, Tuula Kieseppä, T. Raij, T. Mäntylä, M. Lindgren, E. Rikandi, W. Stoecker, B. Teegen, Jaana Suvisaari

Research output: Contribution to journalArticleScientificpeer-review

15 Citations (Scopus)

Abstract

It may be challenging to distinguish autoimmune encephalitis associated with anti-neuronal autoantibodies from primary psychiatric disorders. Here, serum was drawn from patients with a first-episode psychosis (n = 70) or a clinical high-risk for psychosis (n = 6) and controls (n = 34). We investigated the serum prevalence of 24 anti-neuronal autoantibodies: IgG antibodies for anti-N-methyl-d-aspartate-type glutamate receptor (anti-NMDAR), glutamate and γ-aminobutyric acid alpha and beta receptors (GABA-a, GABA-b), alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor (AMPA), glycine receptor (GlyR), metabotropic glutamate receptor 1 and 5 (mGluR1, mGluR5), anti-Tr/Delta/notch-like epidermal growth factor-related receptor (DNER), contactin-associated protein-like 2 (CASPR2), myelin oligodendrocyte glycoprotein (MOG), glutamic acid decarboxylase-65 (GAD65), collapsin response mediator protein 5/crossveinless-2 (CV2), aquaporin-4 (AQP4), anti-dipeptidyl-peptidase-like protein-6 (DPPX), type 1 anti-neuronal nuclear antibody (ANNA-1, Hu), Ri, Yo, IgLON5, Ma2, zinc finger protein 4 (ZIC4), Rho GTPase-activating protein 26, amphiphysin, and recoverin, as well as IgA and IgM for dopamine-2-receptor (DRD2). Anti-NMDA IgG antibodies were positive with serum titer 1:320 in one patient with a clinical high risk for psychosis. He did not receive a diagnosis of encephalitis after comprehensive neurological evaluation. All other antineuronal autoantibodies were negative and there were no additional findings with immunohistochemistry of brain issues.

Original languageEnglish
Pages (from-to)404-407
JournalSchizophrenia Research
Volume192
DOIs
Publication statusPublished - 2018
MoE publication typeA1 Journal article-refereed

Keywords

  • Anti-glycine receptor
  • Anti-neuronal antibodies
  • Autoimmunity
  • Clinical high risk of psychosis
  • First episode psychosis
  • N-methyl d-aspartate (NMDA) receptor

Fingerprint Dive into the research topics of 'Anti-neuronal anti-bodies in patients with early psychosis'. Together they form a unique fingerprint.

  • Cite this

    Mantere, O., Saarela, M., Kieseppä, T., Raij, T., Mäntylä, T., Lindgren, M., ... Suvisaari, J. (2018). Anti-neuronal anti-bodies in patients with early psychosis. Schizophrenia Research, 192, 404-407. https://doi.org/10.1016/j.schres.2017.04.027