Anti-angiogenic and anti-inflammatory activity of the summer truffle (Tuber aestivum Vittad.) extracts and a correlation with the chemical constituents identified therein

Sandesh J. Marathe*, Wahiba Hamzi, Abdulla M. Bashein, Jan Deska, Tuulikki Seppänen-Laakso, Rekha S. Singhal, Salem Shamekh

*Corresponding author for this work

Research output: Contribution to journalArticleScientificpeer-review

1 Citation (Scopus)

Abstract

Fungi are a huge source of unexplored bioactive compounds. Owing to their biological activities, several fungi have shown commercial application in the health industry. Tuber aestivum Vittad. is one such edible fungi with an immense scope for practical biological applications. In the present study, the anti-angiogenic activity of petroleum ether and ethanol extracts of T. aestivum was investigated using the chick chorioallantoic membrane assay and compared to the positive controls silibinin and lenalidomide. Both the extracts showed a dose-dependent anti-angiogenic response. The extracts were also assessed for their anti-inflammatory potential by lipoxygenase-inhibition assay. The IC50 values for LOX inhibition assay, computed by the Boltzmann plot, were 368.5, 147.3 and 40.2 µg/mL, for the petroleum ether extract, ethanol extract, and the positive control ascorbic acid, respectively. The ethanol extract of T. aestivum showed superior anti-angiogenic and anti-inflammatory activity than the petroleum ether extract. Compositional investigation of the extracts by GC-MS revealed the presence of various bioactive compounds. The compounds were correlated to their anti-angiogenic and anti-inflammatory activity based on a meticulous literature search.
Original languageEnglish
Article number109699
Number of pages9
JournalFOOD RESEARCH INTERNATIONAL
Volume137
Early online date18 Sep 2020
DOIs
Publication statusPublished - Nov 2020
MoE publication typeA1 Journal article-refereed

Keywords

  • truffles
  • Tuber aestivum
  • chick chorioallanotic-membrane (CAM) assay
  • anti-angiogenic
  • LOX-inhibitiors
  • anti-inflammatory

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