An Unlockable–Relockable Iron Cage by Subcomponent Self-Assembly

Prasenjit Mal, David Schultz, Ngong Kodiah Beyeh, Kari Rissanen, Jonathan Nitschke

Research output: Contribution to journalArticleScientificpeer-review

271 Citations (Scopus)


Linear diamine and formylpyridine subcomponents form a tetrahedral cage with iron(II) in water (see scheme). This cage traps hydrophobic guests with high specificity within a rigid cavity, isolating them from the aqueous environment. The cage may be broken, releasing the guest, upon the addition of a triamine. It may also be unlocked by adding acid, allowing the guest to be reversibly released until base is added, relocking it within.
Original languageEnglish
Pages (from-to)8297–8301
JournalAngewandte Chemie (International Edition)
Issue number43
Publication statusPublished - Oct 2008
MoE publication typeA1 Journal article-refereed


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