An ultrasonically actuated fine needle enhances biopsy sample yield

Emanuele Perra, Eetu Lampsijarvi, Goncalo Barreto, Muhammad Arif, Tuomas Puranen, Edward Haeggstrom, Kenneth P.H. Pritzker, Heikki J. Nieminen

Research output: Chapter in Book/Report/Conference proceedingConference article in proceedingsScientificpeer-review


Fine-needle aspiration biopsy (FNAB) is a well-known procedure employed in the diagnostics of various tissue pathologies. Despite the common use of fine-needles in biopsy, substantial limitations related to the yield insufficiency of the biopsy sample still remain. In this study, we employed a custom-made ultrasonic device operating at 33 kHz to induce flexural standing waves in a standard 21 G medical needle. This was followed by obtaining tissue samples with the method we call ultrasound-enhanced FNAB (USeFNAB) in different bovine tissues ex vivo. We demonstrated that the yield of USeFNAB was on average up to 3-6 x compared to the yield obtained with the FNAB approach. Histologically relevant structures were detected under microscopy in samples obtained with both techniques. USeFNAB represents a promising candidate for resolving the issue of sample insufficiency, which largely limits the reliability of the FNAB approach.

Original languageEnglish
Title of host publicationIUS 2020 - International Ultrasonics Symposium, Proceedings
Number of pages4
ISBN (Electronic)9781728154480
Publication statusPublished - 7 Sept 2020
MoE publication typeA4 Conference publication
EventIEEE International Ultrasonics Symposium - Las Vegas, United States
Duration: 7 Sept 202011 Sept 2020

Publication series

NameIEEE International Ultrasonics Symposium
ISSN (Print)1948-5719
ISSN (Electronic)1948-5727


ConferenceIEEE International Ultrasonics Symposium
Abbreviated titleIUS
Country/TerritoryUnited States
CityLas Vegas
OtherVirtual conference


  • Biomedical engineering
  • Fine-needle aspiration biopsy
  • Medical devices
  • Needles
  • Nonlinear ultrasound


Dive into the research topics of 'An ultrasonically actuated fine needle enhances biopsy sample yield'. Together they form a unique fingerprint.

Cite this