An ultrasonically actuated fine needle enhances biopsy sample yield

Emanuele Perra, Eetu Lampsijarvi, Goncalo Barreto, Muhammad Arif, Tuomas Puranen, Edward Haeggstrom, Kenneth P.H. Pritzker, Heikki J. Nieminen

Research output: Chapter in Book/Report/Conference proceedingConference contributionScientificpeer-review

Abstract

Fine-needle aspiration biopsy (FNAB) is a well-known procedure employed in the diagnostics of various tissue pathologies. Despite the common use of fine-needles in biopsy, substantial limitations related to the yield insufficiency of the biopsy sample still remain. In this study, we employed a custom-made ultrasonic device operating at 33 kHz to induce flexural standing waves in a standard 21 G medical needle. This was followed by obtaining tissue samples with the method we call ultrasound-enhanced FNAB (USeFNAB) in different bovine tissues ex vivo. We demonstrated that the yield of USeFNAB was on average up to 3-6 x compared to the yield obtained with the FNAB approach. Histologically relevant structures were detected under microscopy in samples obtained with both techniques. USeFNAB represents a promising candidate for resolving the issue of sample insufficiency, which largely limits the reliability of the FNAB approach.

Original languageEnglish
Title of host publicationIUS 2020 - International Ultrasonics Symposium, Proceedings
PublisherIEEE Computer Society
Number of pages4
ISBN (Electronic)9781728154480
DOIs
Publication statusPublished - 7 Sep 2020
MoE publication typeA4 Article in a conference publication
EventIEEE International Ultrasonics Symposium - Las Vegas, United States
Duration: 7 Sep 202011 Sep 2020

Publication series

NameIEEE International Ultrasonics Symposium
PublisherIEEE
Volume2020-September
ISSN (Print)1948-5719
ISSN (Electronic)1948-5727

Conference

ConferenceIEEE International Ultrasonics Symposium
Abbreviated titleIUS
Country/TerritoryUnited States
CityLas Vegas
Period07/09/202011/09/2020
OtherVirtual conference

Keywords

  • Biomedical engineering
  • Fine-needle aspiration biopsy
  • Medical devices
  • Needles
  • Nonlinear ultrasound

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