An overview of nanoparticle based delivery for treatment of inner ear disorders

Ilmari Pyykkö*, Jing Zou, Annelies Schrott-Fischer, Rudolf Glueckert, Paavo Kinnunen

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingChapterScientificpeer-review

16 Citations (Scopus)

Abstract

Nanoparticles offer new possibilities for inner ear treatment as they can carry a variety of drugs, protein, and nucleic acids to inner ear. Nanoparticles are equipped with several functions such as targetability, immuno-transparency, biochemical stability, and ability to be visualized in vivo and in vitro. A group of novel peptides can be attached to the surface of nanoparticles that will enhance the cell entry, endosomal escape, and nuclear targeting. Eight different types of nanoparticles with different payload carrying strategies are available now. The transtympanic delivery of nanoparticles indicates that, depending on the type of nanoparticle, different migration pathways into the inner ear can be employed, and that optimal carriers can be designed according to the intended cargo. The use of nanoparticles as drug/gene carriers is especially attractive in conjunction with cochlear implantation or even as an inclusion in the implant as a drug/ gene reservoir.

Original languageEnglish
Title of host publicationMethods in Molecular Biology
Pages363-415
Number of pages53
Volume1427
DOIs
Publication statusPublished - 2016
MoE publication typeA3 Part of a book or another research book

Publication series

NameMethods in Molecular Biology
Volume1427
ISSN (Print)1064-3745

Keywords

  • Gene therapy
  • Growth factor delivery
  • Repair of inner ear
  • Targeted drug delivery

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