An improved method for synthesis of non-symmetric triarylpyridines

Arvind Negi, Styliana I. Mirallai, Saidulu Konda, Paul V. Murphy

Research output: Contribution to journalArticleScientificpeer-review


The optimization of a multicomponent reaction, to prepare triarylpyridines (triphenylpyridine), and which includes 17 examples where each aryl substituent is distinct (non-symmetric pyridine) is reported. The non-symmetric triarylpyridine aqrar forming reaction involves the sequential addition of two different acetophenones to a benzylamine in DMF in the presence of copper (I) iodide (20 mol %), methanolic ammonia (2 equiv.), and oxygen. The optimized method was used to give twenty five different triarylpyridines in 43–91% yield, including products with a thiophene substituent and bipyridines.
Original languageEnglish
Article number132930
Number of pages13
Early online date17 Aug 2022
Publication statusPublished - 27 Aug 2022
MoE publication typeA1 Journal article-refereed


  • pyridine synthesis
  • copper iodide
  • multicomponent reactors
  • oxidative elimination


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