An additive Gaussian process regression model for interpretable non-parametric analysis of longitudinal data

Research output: Contribution to journalArticleScientificpeer-review

Researchers

Research units

  • Cardiff University
  • Åbo Akademi University
  • University of Auckland
  • Broad Institute

Abstract

Biomedical research typically involves longitudinal study designs where samples from individuals are measured repeatedly over time and the goal is to identify risk factors (covariates) that are associated with an outcome value. General linear mixed effect models are the standard workhorse for statistical analysis of longitudinal data. However, analysis of longitudinal data can be complicated for reasons such as difficulties in modelling correlated outcome values, functional (time-varying) covariates, nonlinear and non-stationary effects, and model inference. We present LonGP, an additive Gaussian process regression model that is specifically designed for statistical analysis of longitudinal data, which solves these commonly faced challenges. LonGP can model time-varying random effects and non-stationary signals, incorporate multiple kernel learning, and provide interpretable results for the effects of individual covariates and their interactions. We demonstrate LonGP’s performance and accuracy by analysing various simulated and real longitudinal -omics datasets.

Details

Original languageEnglish
Article number1798
Pages (from-to)1-11
Number of pages11
JournalNature Communications
Volume10
Issue number1
Publication statusPublished - 17 Apr 2019
MoE publication typeA1 Journal article-refereed

    Research areas

  • OUT CROSS-VALIDATION, INFERENCE

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