Altered working memory-related brain responses and white matter microstructure in extremely preterm-born children at school age

Maksym Tokariev, Virve Vuontela, Piia Lönnberg, Aulikki Lano, Jaana Perkola, Elina Wolford, Sture Andersson, Marjo Metsäranta, Synnöve Carlson

Research output: Contribution to journalArticleScientificpeer-review

5 Citations (Scopus)
52 Downloads (Pure)

Abstract

Preterm birth poses a risk for neurocognitive and behavioral development. Preterm children, who have not been diagnosed with neurological or cognitive deficits, enter normal schools and are expected to succeed as their term-born peers. Here we tested the hypotheses that despite an uneventful development after preterm birth, these children might exhibit subtle abnormalities in brain function and white-matter microstructure at school-age. We recruited 7.5-year-old children born extremely prematurely (<28 weeks’ gestation), and age- and gender-matched term-born controls (≥37 weeks’ gestation). We applied fMRI during working-memory (WM) tasks, and investigated white-matter microstructure with diffusion tensor imaging. Compared with controls, preterm-born children performed WM tasks less accurately, had reduced activation in several right prefrontal areas, and weaker deactivation of right temporal lobe areas. The weaker prefrontal activation correlated with poorer WM performance. Preterm-born children had higher fractional anisotropy (FA) and lower diffusivity than controls in several white-matter areas, and in the posterior cerebellum, the higher FA associated with poorer visuospatial test scores. In controls, higher FA and lower diffusivity correlated with faster WM performance. Together these findings demonstrate weaker WM-related brain activations and altered white matter microstructure in children born extremely preterm, who had normal global cognitive ability.
Original languageEnglish
Article number103615
Pages (from-to)1-14
Number of pages14
JournalBrain and Cognition
Volume136
DOIs
Publication statusPublished - 2019
MoE publication typeA1 Journal article-refereed

Keywords

  • Diffusion tensor imaging
  • Functional MRI
  • Pediatric imaging
  • Prematurity
  • Working memory

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