Alterations in Spontaneous Brain Oscillations during Stroke Recovery

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Alterations in Spontaneous Brain Oscillations during Stroke Recovery. / Laaksonen, Kristina; Helle, Liisa; Parkkonen, Lauri; Kirveskari, Erika; Makela, Jyrki P.; Mustanoja, Satu; Tatlisumak, Turgut; Kaste, Markku; Forss, Nina.

In: PloS one, Vol. 8, No. 4, e61146, 2013, p. 1-9.

Research output: Contribution to journalArticleScientificpeer-review

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Laaksonen, K, Helle, L, Parkkonen, L, Kirveskari, E, Makela, JP, Mustanoja, S, Tatlisumak, T, Kaste, M & Forss, N 2013, 'Alterations in Spontaneous Brain Oscillations during Stroke Recovery', PloS one, vol. 8, no. 4, e61146, pp. 1-9. https://doi.org/10.1371/journal.pone.0061146

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Laaksonen, Kristina ; Helle, Liisa ; Parkkonen, Lauri ; Kirveskari, Erika ; Makela, Jyrki P. ; Mustanoja, Satu ; Tatlisumak, Turgut ; Kaste, Markku ; Forss, Nina. / Alterations in Spontaneous Brain Oscillations during Stroke Recovery. In: PloS one. 2013 ; Vol. 8, No. 4. pp. 1-9.

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@article{d4de488e369f43bf9aeea37714673c86,
title = "Alterations in Spontaneous Brain Oscillations during Stroke Recovery",
abstract = "Amplitude or frequency alterations of spontaneous brain oscillations may reveal pathological phenomena in the brain or predict recovery from brain lesions, but the temporal evolution and the functional significance of these changes is not well known. We performed follow-up recordings of spontaneous brain oscillations with whole-head MEG in 16 patients with first-ever stroke in the middle cerebral artery territory, affecting upper limb motor function, 1–7 days (T0), 1 month (T1), and 3 months (T2) after stroke, with concomitant clinical examination. Clinical test results improved significantly from T0 to T1 or T2. During recovery (at T1 and T2), the strength of temporo–parietal ∼10-Hz oscillations in the affected hemisphere (AH) was increased as compared with the unaffected hemisphere. Abnormal low-frequency magnetic activity (ALFMA) at ∼1 Hz in the AH was detected in the perilesional cortex in seven patients at T0. In four of these, ALFMA persisted at T2. In patients with ALFMA, the lesion size was significantly larger than in the rest of the patients, and worse clinical outcome was observed in patients with persisting ALFMA. Our results indicate that temporo–parietal ∼10-Hz oscillations are enhanced in the AH during recovery from stroke. Moreover, stroke causes ALFMA, which seems to persist in patients with worse clinical outcome.",
author = "Kristina Laaksonen and Liisa Helle and Lauri Parkkonen and Erika Kirveskari and Makela, {Jyrki P.} and Satu Mustanoja and Turgut Tatlisumak and Markku Kaste and Nina Forss",
year = "2013",
doi = "10.1371/journal.pone.0061146",
language = "English",
volume = "8",
pages = "1--9",
journal = "PloS one",
issn = "1932-6203",
publisher = "Public Library of Science",
number = "4",

}

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TY - JOUR

T1 - Alterations in Spontaneous Brain Oscillations during Stroke Recovery

AU - Laaksonen, Kristina

AU - Helle, Liisa

AU - Parkkonen, Lauri

AU - Kirveskari, Erika

AU - Makela, Jyrki P.

AU - Mustanoja, Satu

AU - Tatlisumak, Turgut

AU - Kaste, Markku

AU - Forss, Nina

PY - 2013

Y1 - 2013

N2 - Amplitude or frequency alterations of spontaneous brain oscillations may reveal pathological phenomena in the brain or predict recovery from brain lesions, but the temporal evolution and the functional significance of these changes is not well known. We performed follow-up recordings of spontaneous brain oscillations with whole-head MEG in 16 patients with first-ever stroke in the middle cerebral artery territory, affecting upper limb motor function, 1–7 days (T0), 1 month (T1), and 3 months (T2) after stroke, with concomitant clinical examination. Clinical test results improved significantly from T0 to T1 or T2. During recovery (at T1 and T2), the strength of temporo–parietal ∼10-Hz oscillations in the affected hemisphere (AH) was increased as compared with the unaffected hemisphere. Abnormal low-frequency magnetic activity (ALFMA) at ∼1 Hz in the AH was detected in the perilesional cortex in seven patients at T0. In four of these, ALFMA persisted at T2. In patients with ALFMA, the lesion size was significantly larger than in the rest of the patients, and worse clinical outcome was observed in patients with persisting ALFMA. Our results indicate that temporo–parietal ∼10-Hz oscillations are enhanced in the AH during recovery from stroke. Moreover, stroke causes ALFMA, which seems to persist in patients with worse clinical outcome.

AB - Amplitude or frequency alterations of spontaneous brain oscillations may reveal pathological phenomena in the brain or predict recovery from brain lesions, but the temporal evolution and the functional significance of these changes is not well known. We performed follow-up recordings of spontaneous brain oscillations with whole-head MEG in 16 patients with first-ever stroke in the middle cerebral artery territory, affecting upper limb motor function, 1–7 days (T0), 1 month (T1), and 3 months (T2) after stroke, with concomitant clinical examination. Clinical test results improved significantly from T0 to T1 or T2. During recovery (at T1 and T2), the strength of temporo–parietal ∼10-Hz oscillations in the affected hemisphere (AH) was increased as compared with the unaffected hemisphere. Abnormal low-frequency magnetic activity (ALFMA) at ∼1 Hz in the AH was detected in the perilesional cortex in seven patients at T0. In four of these, ALFMA persisted at T2. In patients with ALFMA, the lesion size was significantly larger than in the rest of the patients, and worse clinical outcome was observed in patients with persisting ALFMA. Our results indicate that temporo–parietal ∼10-Hz oscillations are enhanced in the AH during recovery from stroke. Moreover, stroke causes ALFMA, which seems to persist in patients with worse clinical outcome.

U2 - 10.1371/journal.pone.0061146

DO - 10.1371/journal.pone.0061146

M3 - Article

VL - 8

SP - 1

EP - 9

JO - PloS one

JF - PloS one

SN - 1932-6203

IS - 4

M1 - e61146

ER -

ID: 879385