All-in-one microfluidic assembly of insulin-loaded pH-responsive nano-in-microparticles for oral insulin delivery

Clarinda Costa, Zehua Liu, João P. Martins, Alexandra Correia, Patrícia Figueiredo, Antti Rahikkala, Wei Li, Jani Seitsonen, Janne Ruokolainen, Sami Pekka Hirvonen, Ana Aguiar-Ricardo, M. Luísa Corvo, Hélder A. Santos

Research output: Contribution to journalArticleScientificpeer-review

1 Citation (Scopus)
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Abstract

Here, a continuous two-step glass-capillary microfluidic technique to produce a multistage oral delivery system is reported. Insulin is successfully encapsulated into liposomes, which are coated with chitosan to improve their mucoadhesion. The encapsulation in an enteric polymer offers protection from the harsh gastric conditions. Insulin permeability is enhanced across an intestinal monolayer.

Original languageEnglish
Pages (from-to)3270-3277
Number of pages8
JournalBiomaterials Science
Volume8
Issue number12
DOIs
Publication statusPublished - 21 Jun 2020
MoE publication typeA1 Journal article-refereed

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