Abstract
Here, a continuous two-step glass-capillary microfluidic technique to produce a multistage oral delivery system is reported. Insulin is successfully encapsulated into liposomes, which are coated with chitosan to improve their mucoadhesion. The encapsulation in an enteric polymer offers protection from the harsh gastric conditions. Insulin permeability is enhanced across an intestinal monolayer.
Original language | English |
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Pages (from-to) | 3270-3277 |
Number of pages | 8 |
Journal | Biomaterials Science |
Volume | 8 |
Issue number | 12 |
DOIs | |
Publication status | Published - 21 Jun 2020 |
MoE publication type | A1 Journal article-refereed |