All-in-one microfluidic assembly of insulin-loaded pH-responsive nano-in-microparticles for oral insulin delivery

Clarinda Costa; Zehua Liu; João P. Martins; Alexandra Correia; Patrícia Figueiredo; Antti Rahikkala; Wei Li; Jani Seitsonen; Janne Ruokolainen; Sami Pekka Hirvonen; Ana Aguiar-Ricardo; M. Luísa Corvo; Hélder A. Santos

doi:10.1039/d0bm00743a

All-in-one microfluidic assembly of insulin-loaded pH-responsive nano-in-microparticles for oral insulin delivery

Clarinda Costa, Zehua Liu, João P. Martins, Alexandra Correia, Patrícia Figueiredo, Antti Rahikkala, Wei Li, Jani Seitsonen, Janne Ruokolainen, Sami Pekka Hirvonen, Ana Aguiar-Ricardo, M. Luísa Corvo, Hélder A. Santos

Research output: Contribution to journal › Article › Scientific › peer-review

1 Citation (Scopus)

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Abstract

Here, a continuous two-step glass-capillary microfluidic technique to produce a multistage oral delivery system is reported. Insulin is successfully encapsulated into liposomes, which are coated with chitosan to improve their mucoadhesion. The encapsulation in an enteric polymer offers protection from the harsh gastric conditions. Insulin permeability is enhanced across an intestinal monolayer.

Original language	English
Pages (from-to)	3270-3277
Number of pages	8
Journal	Biomaterials Science
Volume	8
Issue number	12
DOIs	https://doi.org/10.1039/d0bm00743a
Publication status	Published - 21 Jun 2020
MoE publication type	A1 Journal article-refereed

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10.1039/d0bm00743a

Costa_All-in-one.d0bm00743a-1Final published version, 2.08 MBLicence: CC BY-NC

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Costa, C., Liu, Z., Martins, J. P., Correia, A., Figueiredo, P., Rahikkala, A., Li, W., Seitsonen, J., Ruokolainen, J., Hirvonen, S. P., Aguiar-Ricardo, A., Corvo, M. L., & Santos, H. A. (2020). All-in-one microfluidic assembly of insulin-loaded pH-responsive nano-in-microparticles for oral insulin delivery. Biomaterials Science, 8(12), 3270-3277. https://doi.org/10.1039/d0bm00743a

Costa, Clarinda ; Liu, Zehua ; Martins, João P. ; Correia, Alexandra ; Figueiredo, Patrícia ; Rahikkala, Antti ; Li, Wei ; Seitsonen, Jani ; Ruokolainen, Janne ; Hirvonen, Sami Pekka ; Aguiar-Ricardo, Ana ; Corvo, M. Luísa ; Santos, Hélder A. / All-in-one microfluidic assembly of insulin-loaded pH-responsive nano-in-microparticles for oral insulin delivery. In: Biomaterials Science. 2020 ; Vol. 8, No. 12. pp. 3270-3277.

@article{d729a50311394afa8480c8de213e07dd,

title = "All-in-one microfluidic assembly of insulin-loaded pH-responsive nano-in-microparticles for oral insulin delivery",

abstract = "Here, a continuous two-step glass-capillary microfluidic technique to produce a multistage oral delivery system is reported. Insulin is successfully encapsulated into liposomes, which are coated with chitosan to improve their mucoadhesion. The encapsulation in an enteric polymer offers protection from the harsh gastric conditions. Insulin permeability is enhanced across an intestinal monolayer.",

author = "Clarinda Costa and Zehua Liu and Martins, {Jo{\~a}o P.} and Alexandra Correia and Patr{\'i}cia Figueiredo and Antti Rahikkala and Wei Li and Jani Seitsonen and Janne Ruokolainen and Hirvonen, {Sami Pekka} and Ana Aguiar-Ricardo and Corvo, {M. Lu{\'i}sa} and Santos, {H{\'e}lder A.}",

year = "2020",

month = jun,

day = "21",

doi = "10.1039/d0bm00743a",

language = "English",

volume = "8",

pages = "3270--3277",

journal = "Biomaterials Science",

issn = "2047-4830",

publisher = "Royal Society of Chemistry",

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Costa, C, Liu, Z, Martins, JP, Correia, A, Figueiredo, P, Rahikkala, A, Li, W, Seitsonen, J , Ruokolainen, J, Hirvonen, SP, Aguiar-Ricardo, A, Corvo, ML & Santos, HA 2020, 'All-in-one microfluidic assembly of insulin-loaded pH-responsive nano-in-microparticles for oral insulin delivery', Biomaterials Science, vol. 8, no. 12, pp. 3270-3277. https://doi.org/10.1039/d0bm00743a

All-in-one microfluidic assembly of insulin-loaded pH-responsive nano-in-microparticles for oral insulin delivery. / Costa, Clarinda; Liu, Zehua; Martins, João P.; Correia, Alexandra; Figueiredo, Patrícia; Rahikkala, Antti; Li, Wei; Seitsonen, Jani ; Ruokolainen, Janne; Hirvonen, Sami Pekka; Aguiar-Ricardo, Ana; Corvo, M. Luísa; Santos, Hélder A.

In: Biomaterials Science, Vol. 8, No. 12, 21.06.2020, p. 3270-3277.

Research output: Contribution to journal › Article › Scientific › peer-review

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AU - Liu, Zehua

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AU - Figueiredo, Patrícia

AU - Rahikkala, Antti

AU - Li, Wei

AU - Seitsonen, Jani

AU - Ruokolainen, Janne

AU - Hirvonen, Sami Pekka

AU - Aguiar-Ricardo, Ana

AU - Corvo, M. Luísa

AU - Santos, Hélder A.

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