Abstract
Starting from biogenic furfurals, an operationally simple and scalable condensation-umpolung-alkylation protocol was employed in the synthesis of racemic furfurylamines. Subsequent enzymatic kinetic resolution by -transaminase or lipase biocatalysts allows for the preparation of functionalized heterocyclic building blocks from biogenic base chemicals in optically pure form.
Original language | English |
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Pages (from-to) | 2093-2099 |
Number of pages | 7 |
Journal | SYNTHESIS: STUTTGART |
Volume | 47 |
Issue number | 14 |
DOIs | |
Publication status | Published - Jul 2015 |
MoE publication type | A1 Journal article-refereed |
Keywords
- furfural
- amines
- umpolung
- biocatalysis
- transaminase
- ASYMMETRIC-SYNTHESIS
- BUILDING-BLOCKS
- REARRANGEMENT
- ARYLATION
- BOND