Albumin Stabilized Fe@C Core–Shell Nanoparticles as Candidates for Magnetic Hyperthermia Therapy

Maria Antonieta Ramírez-Morales; Anastasia E. Goldt; Polina M. Kalachikova; Javier A. Ramirez B; Masashi Suzuki; Alexey N. Zhigach; Asma Ben Salah; Liliya I. Shurygina; Sergey D. Shandakov; Timofei Zatsepin; Dmitry V. Krasnikov; Toru Maekawa; Evgeny N. Nikolaev; Albert G. Nasibulin

doi:10.3390/nano12162869

Albumin Stabilized Fe@C Core–Shell Nanoparticles as Candidates for Magnetic Hyperthermia Therapy

Maria Antonieta Ramírez-Morales, Anastasia E. Goldt^*, Polina M. Kalachikova, Javier A. Ramirez B, Masashi Suzuki, Alexey N. Zhigach, Asma Ben Salah, Liliya I. Shurygina, Sergey D. Shandakov, Timofei Zatsepin, Dmitry V. Krasnikov, Toru Maekawa, Evgeny N. Nikolaev, Albert G. Nasibulin^*

^*Corresponding author for this work

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Abstract

Carbon-encapsulated iron nanoparticles (Fe@C) with a mean diameter of 15 nm have been synthesized using evaporation–condensation flow–levitation method by the direct iron-carbon gas-phase reaction at high temperatures. Further, Fe@C were stabilized with bovine serum albumin (BSA) coating, and their electromagnetic properties were evaluated to test their performance in magnetic hyperthermia therapy (MHT) through a specific absorption rate (SAR). Heat generation was observed at different Fe@C concentrations (1, 2.5, and 5 mg/mL) when applied 331 kHz and 60 kA/m of an alternating magnetic field, resulting in SAR values of 437.64, 129.36, and 50.4 W/g for each concentration, respectively. Having such high SAR values at low concentrations, obtained material is ideal for use in MHT.

Original language	English
Article number	2869
Number of pages	9
Journal	Nanomaterials
Volume	12
Issue number	16
DOIs	https://doi.org/10.3390/nano12162869
Publication status	Published - Aug 2022
MoE publication type	A1 Journal article-refereed

Funding

This research was founded by the Council on grants of the President of the Russian Federation grant number HIII-1330.2022.1.3 and by Russian Science Foundation (Project No 22-13-00436). We acknowledge the Ministry of Science and Higher Education of the Russian Federation (project No. FZSR-2020-0007 in the framework of the state assignment No. 075-03-2020-097/1).

Keywords

core–shell nanoparticles
ferromagnetic particles
flow-levitation method
iron nanoparticles
magnetic hyperthermia

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CHEM_Ramirez-Morales_et_al_Albumin_Stabilized_2022_NanomaterialsFinal published version, 685 KBLicence: CC BY

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Ramírez-Morales, M. A., Goldt, A. E., Kalachikova, P. M., Ramirez B, J. A., Suzuki, M., Zhigach, A. N., Ben Salah, A., Shurygina, L. I., Shandakov, S. D., Zatsepin, T., Krasnikov, D. V., Maekawa, T., Nikolaev, E. N., & Nasibulin, A. G. (2022). Albumin Stabilized Fe@C Core–Shell Nanoparticles as Candidates for Magnetic Hyperthermia Therapy. Nanomaterials, 12(16), Article 2869. https://doi.org/10.3390/nano12162869

@article{e0a2e4506f744ff68020a82196802df6,

title = "Albumin Stabilized Fe@C Core–Shell Nanoparticles as Candidates for Magnetic Hyperthermia Therapy",

abstract = "Carbon-encapsulated iron nanoparticles (Fe@C) with a mean diameter of 15 nm have been synthesized using evaporation–condensation flow–levitation method by the direct iron-carbon gas-phase reaction at high temperatures. Further, Fe@C were stabilized with bovine serum albumin (BSA) coating, and their electromagnetic properties were evaluated to test their performance in magnetic hyperthermia therapy (MHT) through a specific absorption rate (SAR). Heat generation was observed at different Fe@C concentrations (1, 2.5, and 5 mg/mL) when applied 331 kHz and 60 kA/m of an alternating magnetic field, resulting in SAR values of 437.64, 129.36, and 50.4 W/g for each concentration, respectively. Having such high SAR values at low concentrations, obtained material is ideal for use in MHT.",

keywords = "core–shell nanoparticles, ferromagnetic particles, flow-levitation method, iron nanoparticles, magnetic hyperthermia",

author = "Ram{\'i}rez-Morales, \{Maria Antonieta\} and Goldt, \{Anastasia E.\} and Kalachikova, \{Polina M.\} and \{Ramirez B\}, \{Javier A.\} and Masashi Suzuki and Zhigach, \{Alexey N.\} and \{Ben Salah\}, Asma and Shurygina, \{Liliya I.\} and Shandakov, \{Sergey D.\} and Timofei Zatsepin and Krasnikov, \{Dmitry V.\} and Toru Maekawa and Nikolaev, \{Evgeny N.\} and Nasibulin, \{Albert G.\}",

note = "Publisher Copyright: {\textcopyright} 2022 by the authors.",

year = "2022",

month = aug,

doi = "10.3390/nano12162869",

language = "English",

volume = "12",

journal = "Nanomaterials",

issn = "2079-4991",

publisher = "MDPI AG",

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Ramírez-Morales, MA, Goldt, AE, Kalachikova, PM, Ramirez B, JA, Suzuki, M, Zhigach, AN, Ben Salah, A, Shurygina, LI, Shandakov, SD, Zatsepin, T, Krasnikov, DV, Maekawa, T, Nikolaev, EN & Nasibulin, AG 2022, 'Albumin Stabilized Fe@C Core–Shell Nanoparticles as Candidates for Magnetic Hyperthermia Therapy', Nanomaterials, vol. 12, no. 16, 2869. https://doi.org/10.3390/nano12162869

TY - JOUR

T1 - Albumin Stabilized Fe@C Core–Shell Nanoparticles as Candidates for Magnetic Hyperthermia Therapy

AU - Ramírez-Morales, Maria Antonieta

AU - Goldt, Anastasia E.

AU - Kalachikova, Polina M.

AU - Ramirez B, Javier A.

AU - Suzuki, Masashi

AU - Zhigach, Alexey N.

AU - Ben Salah, Asma

AU - Shurygina, Liliya I.

AU - Shandakov, Sergey D.

AU - Zatsepin, Timofei

AU - Krasnikov, Dmitry V.

AU - Maekawa, Toru

AU - Nikolaev, Evgeny N.

AU - Nasibulin, Albert G.

PY - 2022/8

Y1 - 2022/8

N2 - Carbon-encapsulated iron nanoparticles (Fe@C) with a mean diameter of 15 nm have been synthesized using evaporation–condensation flow–levitation method by the direct iron-carbon gas-phase reaction at high temperatures. Further, Fe@C were stabilized with bovine serum albumin (BSA) coating, and their electromagnetic properties were evaluated to test their performance in magnetic hyperthermia therapy (MHT) through a specific absorption rate (SAR). Heat generation was observed at different Fe@C concentrations (1, 2.5, and 5 mg/mL) when applied 331 kHz and 60 kA/m of an alternating magnetic field, resulting in SAR values of 437.64, 129.36, and 50.4 W/g for each concentration, respectively. Having such high SAR values at low concentrations, obtained material is ideal for use in MHT.

AB - Carbon-encapsulated iron nanoparticles (Fe@C) with a mean diameter of 15 nm have been synthesized using evaporation–condensation flow–levitation method by the direct iron-carbon gas-phase reaction at high temperatures. Further, Fe@C were stabilized with bovine serum albumin (BSA) coating, and their electromagnetic properties were evaluated to test their performance in magnetic hyperthermia therapy (MHT) through a specific absorption rate (SAR). Heat generation was observed at different Fe@C concentrations (1, 2.5, and 5 mg/mL) when applied 331 kHz and 60 kA/m of an alternating magnetic field, resulting in SAR values of 437.64, 129.36, and 50.4 W/g for each concentration, respectively. Having such high SAR values at low concentrations, obtained material is ideal for use in MHT.

KW - core–shell nanoparticles

KW - ferromagnetic particles

KW - flow-levitation method

KW - iron nanoparticles

KW - magnetic hyperthermia

UR - https://www.scopus.com/pages/publications/85137409811

U2 - 10.3390/nano12162869

DO - 10.3390/nano12162869

M3 - Article

AN - SCOPUS:85137409811

SN - 2079-4991

VL - 12

JO - Nanomaterials

JF - Nanomaterials

IS - 16

M1 - 2869

ER -

Albumin Stabilized Fe@C Core–Shell Nanoparticles as Candidates for Magnetic Hyperthermia Therapy

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