Albumin Stabilized Fe@C Core–Shell Nanoparticles as Candidates for Magnetic Hyperthermia Therapy

Maria Antonieta Ramírez-Morales, Anastasia E. Goldt*, Polina M. Kalachikova, Javier A. Ramirez B, Masashi Suzuki, Alexey N. Zhigach, Asma Ben Salah, Liliya I. Shurygina, Sergey D. Shandakov, Timofei Zatsepin, Dmitry V. Krasnikov, Toru Maekawa, Evgeny N. Nikolaev, Albert G. Nasibulin*

*Corresponding author for this work

Research output: Contribution to journalArticleScientificpeer-review

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Carbon-encapsulated iron nanoparticles (Fe@C) with a mean diameter of 15 nm have been synthesized using evaporation–condensation flow–levitation method by the direct iron-carbon gas-phase reaction at high temperatures. Further, Fe@C were stabilized with bovine serum albumin (BSA) coating, and their electromagnetic properties were evaluated to test their performance in magnetic hyperthermia therapy (MHT) through a specific absorption rate (SAR). Heat generation was observed at different Fe@C concentrations (1, 2.5, and 5 mg/mL) when applied 331 kHz and 60 kA/m of an alternating magnetic field, resulting in SAR values of 437.64, 129.36, and 50.4 W/g for each concentration, respectively. Having such high SAR values at low concentrations, obtained material is ideal for use in MHT.

Original languageEnglish
Article number2869
Number of pages9
Issue number16
Publication statusPublished - Aug 2022
MoE publication typeA1 Journal article-refereed


  • core–shell nanoparticles
  • ferromagnetic particles
  • flow-levitation method
  • iron nanoparticles
  • magnetic hyperthermia


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