Additive Manufacturing of Bioactive Poly(trimethylene carbonate)/β-Tricalcium Phosphate Composites for Bone Regeneration
Research output: Contribution to journal › Article › Scientific › peer-review
Implants of bioresorbable materials combined with osteoconductive calcium phosphate ceramics show promising results to replace and repair damaged bone tissue. Here we present additive manufacturing of patient-specific porous scaffolds of poly(trimethylene carbonate) (PTMC) including high amounts of β-tricalcium phosphate (β-TCP). Tensile testing of composite networks showed that addition of β-tricalcium phosphate reinforces the composites significantly. Three-dimensional structures containing up to 60 wt % β-TCP could be built by stereolithography. By lowering the content to 51 wt %, manufacturing of a large-sized patient-specific prototype was possible at high resolution. Closer examination revealed that the created scaffolds contained more β-TCP on the surface of the builds. Stereolithography therefore provides a manufacturing technique where the bioactive agent is directly available for creating an enhanced microenvironment for cell growth. The biocompatibility and bioresorption of PTMC coupled with the osteoconductivity of β-TCP are an important candidate to consider in additive manufacturing of bone regeneration implants.
|Publication status||Published - 10 Feb 2020|
|MoE publication type||A1 Journal article-refereed|