Active diffusion of nanoparticles of maternal origin within the embryonic brain

Research output: Contribution to journalArticleScientificpeer-review

Researchers

  • Mikhail Yuryev
  • Mónica Pa Ferreira
  • Vimalkumar Balasubramanian
  • Alexandra Mr Correia
  • Ermei M. Mäkilä
  • Ville Jokinen
  • Liliia Andriichuk
  • Marianna Kemell
  • Jarno J. Salonen
  • Jouni T. Hirvonen
  • Hélder A. Santos
  • Claudio Rivera

Research units

  • University of Helsinki
  • University of Turku
  • Institut de Neurobiologie de la Méditerranée
  • Aix-Marseille Université

Abstract

Aim: To investigate porous silicon (PSi) nanoparticles (NPs) behavior in the embryonic brain. Materials & methods: Fluorescently labeled PSi NPs were injected into the embryonic brains intraventricularly and to the mother intravenously (iv.). Brain histology from different time points up to 3 days was analyzed and live brains imaged with two-photon microscopy. Results: PSi NPs were able to penetrate 80% of the embryonic cortical depth. Particle motility was confirmed in real-time in vivo. PSi NPs were able to penetrate the embryonic cortex after either iv. maternal or intraventricular injection. No developmental of macromorphological changes or increased cell apoptosis was observed. Conclusion: PSi NPs penetrate deep in the brain tissues of embryos after intraventricular injection and after iv. injection to the mother.

Details

Original languageEnglish
Pages (from-to)2471-2481
Number of pages11
JournalNanomedicine
Volume11
Issue number19
Publication statusPublished - 1 Oct 2016
MoE publication typeA1 Journal article-refereed

    Research areas

  • development, embryos, mother-embryo interface, nanoparticles, porous silicon

ID: 9793845