Active diffusion of nanoparticles of maternal origin within the embryonic brain

Mikhail Yuryev; Mónica Pa Ferreira; Vimalkumar Balasubramanian; Alexandra Mr Correia; Ermei M. Mäkilä; Ville Jokinen; Liliia Andriichuk; Marianna Kemell; Jarno J. Salonen; Jouni T. Hirvonen; Hélder A. Santos; Claudio Rivera

doi:10.2217/nnm-2016-0207

Active diffusion of nanoparticles of maternal origin within the embryonic brain

Mikhail Yuryev^*
, Mónica Pa Ferreira
, Vimalkumar Balasubramanian
, Alexandra Mr Correia
, Ermei M. Mäkilä
, Ville Jokinen
, Liliia Andriichuk
, Marianna Kemell
, Jarno J. Salonen
, Jouni T. Hirvonen
, Hélder A. Santos
, Claudio Rivera

^*Corresponding author for this work

Department of Chemistry and Materials Science

Research output: Contribution to journal › Article › Scientific › peer-review

6 Citations (Scopus)

Abstract

Aim: To investigate porous silicon (PSi) nanoparticles (NPs) behavior in the embryonic brain. Materials & methods: Fluorescently labeled PSi NPs were injected into the embryonic brains intraventricularly and to the mother intravenously (iv.). Brain histology from different time points up to 3 days was analyzed and live brains imaged with two-photon microscopy. Results: PSi NPs were able to penetrate 80% of the embryonic cortical depth. Particle motility was confirmed in real-time in vivo. PSi NPs were able to penetrate the embryonic cortex after either iv. maternal or intraventricular injection. No developmental of macromorphological changes or increased cell apoptosis was observed. Conclusion: PSi NPs penetrate deep in the brain tissues of embryos after intraventricular injection and after iv. injection to the mother.

Original language	English
Pages (from-to)	2471-2481
Number of pages	11
Journal	Nanomedicine
Volume	11
Issue number	19
DOIs	https://doi.org/10.2217/nnm-2016-0207
Publication status	Published - 1 Oct 2016
MoE publication type	A1 Journal article-refereed

Keywords

development
embryos
mother-embryo interface
nanoparticles
porous silicon

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10.2217/nnm-2016-0207

Cite this

@article{6bcd6054be5c4b099f307d1fb65b2705,

title = "Active diffusion of nanoparticles of maternal origin within the embryonic brain",

abstract = "Aim: To investigate porous silicon (PSi) nanoparticles (NPs) behavior in the embryonic brain. Materials \& methods: Fluorescently labeled PSi NPs were injected into the embryonic brains intraventricularly and to the mother intravenously (iv.). Brain histology from different time points up to 3 days was analyzed and live brains imaged with two-photon microscopy. Results: PSi NPs were able to penetrate 80\% of the embryonic cortical depth. Particle motility was confirmed in real-time in vivo. PSi NPs were able to penetrate the embryonic cortex after either iv. maternal or intraventricular injection. No developmental of macromorphological changes or increased cell apoptosis was observed. Conclusion: PSi NPs penetrate deep in the brain tissues of embryos after intraventricular injection and after iv. injection to the mother.",

keywords = "development, embryos, mother-embryo interface, nanoparticles, porous silicon",

author = "Mikhail Yuryev and Ferreira, \{M{\'o}nica Pa\} and Vimalkumar Balasubramanian and Correia, \{Alexandra Mr\} and M{\"a}kil{\"a}, \{Ermei M.\} and Ville Jokinen and Liliia Andriichuk and Marianna Kemell and Salonen, \{Jarno J.\} and Hirvonen, \{Jouni T.\} and Santos, \{H{\'e}lder A.\} and Claudio Rivera",

year = "2016",

month = oct,

day = "1",

doi = "10.2217/nnm-2016-0207",

language = "English",

volume = "11",

pages = "2471--2481",

journal = "Nanomedicine",

issn = "1743-5889",

publisher = "Taylor \& Francis",

number = "19",

}

TY - JOUR

T1 - Active diffusion of nanoparticles of maternal origin within the embryonic brain

AU - Yuryev, Mikhail

AU - Ferreira, Mónica Pa

AU - Balasubramanian, Vimalkumar

AU - Correia, Alexandra Mr

AU - Mäkilä, Ermei M.

AU - Jokinen, Ville

AU - Andriichuk, Liliia

AU - Kemell, Marianna

AU - Salonen, Jarno J.

AU - Hirvonen, Jouni T.

AU - Santos, Hélder A.

AU - Rivera, Claudio

PY - 2016/10/1

Y1 - 2016/10/1

N2 - Aim: To investigate porous silicon (PSi) nanoparticles (NPs) behavior in the embryonic brain. Materials & methods: Fluorescently labeled PSi NPs were injected into the embryonic brains intraventricularly and to the mother intravenously (iv.). Brain histology from different time points up to 3 days was analyzed and live brains imaged with two-photon microscopy. Results: PSi NPs were able to penetrate 80% of the embryonic cortical depth. Particle motility was confirmed in real-time in vivo. PSi NPs were able to penetrate the embryonic cortex after either iv. maternal or intraventricular injection. No developmental of macromorphological changes or increased cell apoptosis was observed. Conclusion: PSi NPs penetrate deep in the brain tissues of embryos after intraventricular injection and after iv. injection to the mother.

AB - Aim: To investigate porous silicon (PSi) nanoparticles (NPs) behavior in the embryonic brain. Materials & methods: Fluorescently labeled PSi NPs were injected into the embryonic brains intraventricularly and to the mother intravenously (iv.). Brain histology from different time points up to 3 days was analyzed and live brains imaged with two-photon microscopy. Results: PSi NPs were able to penetrate 80% of the embryonic cortical depth. Particle motility was confirmed in real-time in vivo. PSi NPs were able to penetrate the embryonic cortex after either iv. maternal or intraventricular injection. No developmental of macromorphological changes or increased cell apoptosis was observed. Conclusion: PSi NPs penetrate deep in the brain tissues of embryos after intraventricular injection and after iv. injection to the mother.

KW - development

KW - embryos

KW - mother-embryo interface

KW - nanoparticles

KW - porous silicon

UR - https://www.scopus.com/pages/publications/84990219809

U2 - 10.2217/nnm-2016-0207

DO - 10.2217/nnm-2016-0207

M3 - Article

AN - SCOPUS:84990219809

SN - 1743-5889

VL - 11

SP - 2471

EP - 2481

JO - Nanomedicine

JF - Nanomedicine

IS - 19

ER -

Active diffusion of nanoparticles of maternal origin within the embryonic brain

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Active diffusion of nanoparticles of maternal origin within the embryonic brain

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Keywords

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