Abnormal brain responses to action observation in complex regional pain syndrome.

Research output: Contribution to journalArticleScientificpeer-review

Researchers

Research units

  • Department of Neurology, Helsinki University Hospital, and Clinical Neurosciences, Neurology, University of Helsinki

Abstract

Patients with complex regional pain syndrome (CRPS) display various abnormalities in central motor function, and their pain is intensified when they perform or just observe motor actions. Here, we examined the abnormalities of brain responses to action observation in CRPS. We analyzed 3-T functional magnetic resonance images from 13 upper-limb CRPS patients (all females, ages 31-58 years) and 13 healthy, age- and sex-matched control subjects. The functional magnetic resonance imaging data were acquired while the subjects viewed brief videos of hand actions shown in the first-person perspective. A pattern-classification analysis was applied to characterize brain areas where the activation pattern differed between CRPS patients and healthy subjects. Brain areas with statistically significant group differences (q < 0.05, false discovery rate corrected) included the hand representation area in the sensorimotor cortex, inferior frontal gyrus, secondary somatosensory cortex, inferior parietal lobule, orbitofrontal cortex, and thalamus. Our findings indicate that CRPS impairs action observation by affecting brain areas related to pain processing and motor control.

Details

Original languageEnglish
Pages (from-to)255–265
Number of pages11
JournalJOURNAL OF PAIN
Volume18
Issue number3
Publication statusPublished - Mar 2017
MoE publication typeA1 Journal article-refereed

    Research areas

  • chronic pain, complex regional pain syndrome, brain, fMRI, action observation, vision

ID: 9848296