A Janus-Type Phthalocyanine for the Assembly of Photoactive DNA Origami Coatings

Asma Rahali, Ahmed Shaukat, Verónica Almeida-Marrero, Bassem Jamoussi, Andrés de la Escosura, Tomás Torres*, Mauri A. Kostiainen*, Eduardo Anaya-Plaza*

*Corresponding author for this work

Research output: Contribution to journalArticleScientificpeer-review

2 Citations (Scopus)
65 Downloads (Pure)


Design and synthesis of novel photosensitizer architectures is a key step toward new multifunctional molecular materials. Photoactive Janus-type molecules provide interesting building blocks for such systems by presenting two well-defined chemical functionalities that can be utilized orthogonally. Herein a multifunctional phthalocyanine is reported, bearing a bulky and positively charged moiety that hinders their aggregation while providing the ability to adhere on DNA origami nanostructures via reversible electrostatic interactions. On the other hand, triethylene glycol moieties render a water-soluble and chemically inert corona that can stabilize the structures. This approach provides insight into the molecular design and synthesis of Janus-type sensitizers that can be combined with biomolecules, rendering optically active biohybrids.

Original languageEnglish
Pages (from-to)1123–1129
Number of pages7
JournalBioconjugate Chemistry
Issue number6
Early online date24 May 2021
Publication statusPublished - 16 Jun 2021
MoE publication typeA1 Journal article-refereed


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