A high-resolution computational localization method for transcranial magnetic stimulation mapping

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A high-resolution computational localization method for transcranial magnetic stimulation mapping. / Aonuma, Shinta; Gomez-Tames, Jose; Laakso, Ilkka; Hirata, Akimasa; Takakura, Tomokazu; Tamura, Manabu; Muragaki, Yoshihiro.

In: NeuroImage, Vol. 172, 15.05.2018, p. 85-93.

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Aonuma, Shinta ; Gomez-Tames, Jose ; Laakso, Ilkka ; Hirata, Akimasa ; Takakura, Tomokazu ; Tamura, Manabu ; Muragaki, Yoshihiro. / A high-resolution computational localization method for transcranial magnetic stimulation mapping. In: NeuroImage. 2018 ; Vol. 172. pp. 85-93.

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@article{6a70564484214a9a9bb12727d5a7d992,
title = "A high-resolution computational localization method for transcranial magnetic stimulation mapping",
abstract = "Background: Transcranial magnetic stimulation (TMS) is used for the mapping of brain motor functions. The complexity of the brain deters determining the exact localization of the stimulation site using simplified methods (e.g., the region below the center of the TMS coil) or conventional computational approaches. Objective: This study aimed to present a high-precision localization method for a specific motor area by synthesizing computed non-uniform current distributions in the brain for multiple sessions of TMS. Methods: Peritumoral mapping by TMS was conducted on patients who had intra-axial brain neoplasms located within or close to the motor speech area. The electric field induced by TMS was computed using realistic head models constructed from magnetic resonance images of patients. A post-processing method was implemented to determine a TMS hotspot by combining the computed electric fields for the coil orientations and positions that delivered high motor-evoked potentials during peritumoral mapping. The method was compared to the stimulation site localized via intraoperative direct brain stimulation and navigated TMS. Results: Four main results were obtained: 1) the dependence of the computed hotspot area on the number of peritumoral measurements was evaluated; 2) the estimated localization of the hand motor area in eight non-affected hemispheres was in good agreement with the position of a so-called “hand-knob”; 3) the estimated hotspot areas were not sensitive to variations in tissue conductivity; and 4) the hand motor areas estimated by this proposal and direct electric stimulation (DES) were in good agreement in the ipsilateral hemisphere of four glioma patients. Conclusion(s): The TMS localization method was validated by well-known positions of the “hand-knob” in brains for the non-affected hemisphere, and by a hotspot localized via DES during awake craniotomy for the tumor-containing hemisphere.",
keywords = "Brain mapping, Brain tumor, Direct electrical stimulation, Hotspot, Transcranial magnetic stimulation, Volume conductor model",
author = "Shinta Aonuma and Jose Gomez-Tames and Ilkka Laakso and Akimasa Hirata and Tomokazu Takakura and Manabu Tamura and Yoshihiro Muragaki",
year = "2018",
month = "5",
day = "15",
doi = "10.1016/j.neuroimage.2018.01.039",
language = "English",
volume = "172",
pages = "85--93",
journal = "NeuroImage",
issn = "1053-8119",

}

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TY - JOUR

T1 - A high-resolution computational localization method for transcranial magnetic stimulation mapping

AU - Aonuma, Shinta

AU - Gomez-Tames, Jose

AU - Laakso, Ilkka

AU - Hirata, Akimasa

AU - Takakura, Tomokazu

AU - Tamura, Manabu

AU - Muragaki, Yoshihiro

PY - 2018/5/15

Y1 - 2018/5/15

N2 - Background: Transcranial magnetic stimulation (TMS) is used for the mapping of brain motor functions. The complexity of the brain deters determining the exact localization of the stimulation site using simplified methods (e.g., the region below the center of the TMS coil) or conventional computational approaches. Objective: This study aimed to present a high-precision localization method for a specific motor area by synthesizing computed non-uniform current distributions in the brain for multiple sessions of TMS. Methods: Peritumoral mapping by TMS was conducted on patients who had intra-axial brain neoplasms located within or close to the motor speech area. The electric field induced by TMS was computed using realistic head models constructed from magnetic resonance images of patients. A post-processing method was implemented to determine a TMS hotspot by combining the computed electric fields for the coil orientations and positions that delivered high motor-evoked potentials during peritumoral mapping. The method was compared to the stimulation site localized via intraoperative direct brain stimulation and navigated TMS. Results: Four main results were obtained: 1) the dependence of the computed hotspot area on the number of peritumoral measurements was evaluated; 2) the estimated localization of the hand motor area in eight non-affected hemispheres was in good agreement with the position of a so-called “hand-knob”; 3) the estimated hotspot areas were not sensitive to variations in tissue conductivity; and 4) the hand motor areas estimated by this proposal and direct electric stimulation (DES) were in good agreement in the ipsilateral hemisphere of four glioma patients. Conclusion(s): The TMS localization method was validated by well-known positions of the “hand-knob” in brains for the non-affected hemisphere, and by a hotspot localized via DES during awake craniotomy for the tumor-containing hemisphere.

AB - Background: Transcranial magnetic stimulation (TMS) is used for the mapping of brain motor functions. The complexity of the brain deters determining the exact localization of the stimulation site using simplified methods (e.g., the region below the center of the TMS coil) or conventional computational approaches. Objective: This study aimed to present a high-precision localization method for a specific motor area by synthesizing computed non-uniform current distributions in the brain for multiple sessions of TMS. Methods: Peritumoral mapping by TMS was conducted on patients who had intra-axial brain neoplasms located within or close to the motor speech area. The electric field induced by TMS was computed using realistic head models constructed from magnetic resonance images of patients. A post-processing method was implemented to determine a TMS hotspot by combining the computed electric fields for the coil orientations and positions that delivered high motor-evoked potentials during peritumoral mapping. The method was compared to the stimulation site localized via intraoperative direct brain stimulation and navigated TMS. Results: Four main results were obtained: 1) the dependence of the computed hotspot area on the number of peritumoral measurements was evaluated; 2) the estimated localization of the hand motor area in eight non-affected hemispheres was in good agreement with the position of a so-called “hand-knob”; 3) the estimated hotspot areas were not sensitive to variations in tissue conductivity; and 4) the hand motor areas estimated by this proposal and direct electric stimulation (DES) were in good agreement in the ipsilateral hemisphere of four glioma patients. Conclusion(s): The TMS localization method was validated by well-known positions of the “hand-knob” in brains for the non-affected hemisphere, and by a hotspot localized via DES during awake craniotomy for the tumor-containing hemisphere.

KW - Brain mapping

KW - Brain tumor

KW - Direct electrical stimulation

KW - Hotspot

KW - Transcranial magnetic stimulation

KW - Volume conductor model

UR - http://www.scopus.com/inward/record.url?scp=85043278092&partnerID=8YFLogxK

U2 - 10.1016/j.neuroimage.2018.01.039

DO - 10.1016/j.neuroimage.2018.01.039

M3 - Article

VL - 172

SP - 85

EP - 93

JO - NeuroImage

JF - NeuroImage

SN - 1053-8119

ER -

ID: 18440019